HSG、VEGF和Ki-67在乳腺癌中的表达及意义

Expressions and significance of HSG,VEGF and Ki- 67 in breast cancer

目的:探讨增殖抑制基因(HSG)、血管内皮生长因子(VEGF)和增殖细胞核抗原(Ki-67)在乳腺癌组织中的表达及临床意义。方法:应用免疫组织化学方法检测唐山市工人医院60例乳腺癌标本、20例乳腺纤维腺瘤标本及20例正常乳腺组织标本中HSG、VEGF和Ki-67的表达。结果:HSG的表达与乳腺癌患者的年龄、肿瘤大小和TNM分期无关,而随着淋巴结的转移而降低(P<0.05);VEGF与乳腺癌患者的年龄及TNM分期无关,而随着肿瘤的增大及淋巴结的转移而明显增高(P<0.05);Ki-67与乳腺癌患者的TNM分期及淋巴结转移有关,随着分期的增高和淋巴结的转移,Ki-67的百分率明显升高(P<0.05)。Spearman等级相关分析显示:在乳腺癌组织中,HSG与VEGF和Ki-67的表达均呈负相关(r=-0.795,P<0.05;r=-0.811,P<0.05),VEGF和Ki-67的表达呈正相关(r=0.383,P<0.05)。结论:HSG在某种程度上可抑制VEGF及Ki-67的表达,减少乳腺癌的侵袭和转移,可见联合检测HSG、VEGF和Ki-67的表达有利于更好地判断乳腺癌的进展及预后。

Objective： To explore the expressions and significance of hyperplasia suppressor gene （HSG）, vascular endothelial growth factor （VEGF） and Ki -67 in breast cancer. Methods： Immunohistochemical method was used to detect the expression levels of HSG, VEGF and Ki - 67 in 60 cases with breast cancer, 20 cases with breast fibroadenoma and 20 cases with normal breast tissue. Results： The expression of HSG in breast cancer was not correlated with age, tumor size and TNM staging, but it decreased with lymph node metastasis （P 〈0. 05 ） . The expression of VEGF in breast cancer was not correlated with age and TNM staging, but it increased significantly with the increase of tumor size and lymph node metastasis （P 〈 0. 05 ） . The expression of Ki - 67 in breast cancer was correlated with TNM staging and lymph node metastasis, and it increased with the increase of TNM staging and lymph node metastasis （P 〈 0. 05 ） . Spearman rank correlation analysis showed that the expression of HSG was negatively correlated with expressions of VEGF and Ki - 67 （ r = - 0. 795, P 〈 0. 05 ; r = - 0. 811, P 〈 0. 05 ） . The expression of VEGF was positively correlated with expression of Ki - 67 （ r = 0. 383, P 〈 0. 05 ） . Conclusion： In a way, HSG can suppress the expressions of VEGF and Ki - 67, and it can reduce invasion and metastasis of breast cancer. Combined detection of HSG, VEGF and Ki - 67 may be beneficial to evaluate development and prognosis of breast cancer.