摘要
目的:探讨精神分裂症患者(Schizophrenia,SCH)错误监测功能是否存在损害。方法将32例精神分裂症患者以及与其人口学资料相匹配的34例正常对照组( HC组)作为研究对象,使用E-prime编制的错误监测任务进行测试。结果 SCH组在选择反应时、评估反应时、不匹配反应时、不确定数,脱失数[分别为(713.22±174.52)ms,(491.14±170.29)ms,(1060.31±130.84)ms,(8.28±12.55)次,(8.00±7.53)次],高于HC组[(560.73±156.94)ms,(395.62±188.03)ms,(989.85±104.33)ms,(2.97±4.13)次,(3.12±6.50)次]均差异有统计学意义( t=-3.737, P=0.000;t=-2.159, P=0.035;t=-2.426, P=0.018;t=-2.282, P=0.022;t=-2.824, P=0.006);SCH组与HC组在全对[(124.72±23.74)/(131.74±21.96)个]、半错[(2.91±10.91)/(0.62±1.10)个]、全错[(15.69±17.64)/(13.35±18.63)个]、半对[(6.83±10.40)/(4.21±7.03)个]以及正确率[(0.831±0.161)/(0.874±0.159)]之间均差异无统计学意义(P>0.05); HAMA、HAMA、病程与错误监测的各项指标均无相关性。结论精神分裂症患者错误监测功能存在损害,可能与前扣带回皮层功能的异常有关。
Objective To investigate the error monitoring function damages on the patients with schizo-phrenia ( SCH) . Methods A total of 32 patients with schizophrenia were compared with matched 34 health con-trols ( HC) on the error monitoring tasks which were compiled by E-Prime. Results The comparison between SCH group ((713.22±174.52)ms,( 491.14±170.29) ms,( 1060.31±130.84) ms,(8.28±12.55)time,( 8.00± 7.53)time respectively) and HC group ((560.73±156.94) ms,(395.62±188.03) ms,(989.85±104.33) ms, (2.97±4.13) times,(3.12±6.50) times) on the reaction time of choice,assessment,incongruent condition,the numbers of uncertain and the numbers of dropout were significant ( t=-3.737, P=0.000;t=-2.159, P=0.035;t=-2.426, P=0.018;t=-2.282, P=0.022;t=-2.824, P=0.006) . The SCH group and HC group did not signifi-cantly difference in Full Correct((124.72±23.74)/(131.74±21.96)times),Full Error((15.69±17.64)/(13.35± 18.63)times),Part Correct((6.83±10.40)/(4.21±7.03)times),Part Error((2.91±10.91)/(0.62±1.10)times) and Accuracy((0.831±0.161)/(0.874±0.159))(P〉0.05).There was no significantly correlation among the course of disease,HAMA,HAMD and the error monitoring. Conclusion These results demonstrate that the error monitoring function damages on the patient with SCH may be involved in the dysfunction of anterior cingulate cortex.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2014年第11期983-985,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(31100812)
关键词
精神分裂症
错误监测
前扣带回皮层
Schizophrenia
Error monitoring
Anterior cingulate cortex