“更眠安汤”治疗肾阴虚型女性更年期失眠的临床疗效

Clinical observation on “Geng Mianan Decoction” in the treatment of menopausal insomnia women with kidney-Yin deficiency

目的 :观察自拟"更眠安汤"治疗肾阴虚型更年期失眠的临床疗效。方法 :选择2012年6月至2014年3月以失眠为主诉的女性更年期综合征患者36例,给予"更眠安汤"治疗,4周为1个疗程,共服用2个疗程。采用匹兹堡睡眠质量指数量表和中医证候积分评估患者治疗第4周和第8周时的临床疗效,并进行比较。结果 :治疗第4周和第8周时的总有效率分别为86.11%(31/36)和91.67%(33/36),主要睡眠指标较治疗前均有改善,差异有统计学意义(P<0.05);除夜间多梦指标外,治疗第8周时较第4周的其余睡眠指标均更佳,差异有统计学意义(P<0.05)。结论 :"更眠安汤"治疗女性更年期失眠症疗效确切,治疗8周的临床疗效更显著。

Objective：To observe the clinical effect of“Geng Mianan Decoction”in the treatment of menopausal insomnia women with Kidney-Yin deficiency. Methods：Thirty-six patients who complained menopausal insomnia were enrolled in the study between June 2012 and March 2014. As 4-week was a period of treatment, the patients received 2 course of“Geng Mianan Decoction”treatment. The clinical effects of treatment in 4 weeks and 8 weeks were eveluated using TCM symptoms scores and Pittsburgh Sleep Quality Index scores. Results：The total effective rate in 4-week treatment and 8-week treatment was 86.11%（31/36） and 91.67%（33/36）respectively. The sleep indicators were signiifcantly improved after treatment when compared with before. There was a statistical signiifcance （P〈0.05）. Except for nocturnal dreams indicator, the rest indicators in 8-week treatment were better than those in 4-week treatment with statistical signiifcancer （P〈0.05）. Conclusion：The“Geng Mianan Decoction”is effective in the treatment of menopausal insomnia. The effect of 8-week treatment is better than 4-wee treatment.