多壁碳纳米管-石墨烯复合膜修饰电极电化学检测异烟肼

The Electrochemical Detection of Isoniazid on a MWCNT/Graphene Composite Film Modified Electrode

采用水合肼还原法制备了多壁碳纳米管（MWCNT）-石墨烯（GR）纳米复合物（MWCNT-GR）,并采用滴涂法制备了此纳米复合物修饰的玻碳电极（MWCNT-GR/GCE）,研究了该修饰电极上异烟肼（Isoniazid,INZ）的电化学行为.结果表明：在pH值为4.0的HAc-NaAc缓冲溶液中,异烟肼在0.35 V处产生一灵敏的不可逆氧化峰.线性扫描伏安法测定异烟肼的线性范围为1.0×10-7~1.0×10-4mol·L-1,检出限为5.0×10-8mol·L-1（S/N=3）.用该法测定了异烟肼注射液中异烟肼的含量,结果令人满意.

The multi-walled carbon nanotube /graphene composite（ MWCNT-GR） were synthesized by using hydrazine as a reduction agent. Based on this,a MWCNT-GR composite film modified glass carbon electrode（ MWCNTGR /GCE） was fabricated. The electrochemical behavior of isoniazid（ INZ） on this modified electrode was investigated carefully. The results showed that an irreversible oxidation peak at 0. 35 V of ING was observed on cyclic voltammograms in HAc-NaAc buffer solution（ pH 4. 0）. The linear range for determination of INZ by LSV was 1. 0 ×10- 7~ 1. 0 × 10- 4mol·L- 1with the detection limit of 5. 0 × 10- 8mol·L- 1（ S/N =3）. Finally,this method was successfully employed to determine isoniazid in injection.