中药结合介入方法治疗急性重症胆囊炎的临床研究

Clinical Effect of Traditional Chinese Medicine with Interventional Treatment for Severe Acute Cholecystitis

目的:分析中药结合介入方法治疗急性重症胆囊炎的疗效。方法:在PTGD基础上加用中药治疗急性重症胆囊炎患者20例(观察组),观察其治疗前后白细胞(WBC)、中性粒细胞百分比(NEUT%)、总胆红素(TB)、结合胆红素(DB)、碱性磷酸酶(ALP)、谷氨酰氨基转移酶(GGT)、丙氨酸转氨酶(ALT)、C反应蛋白(CRP)的变化及住院天数、抗生素使用时间、住院费用情况,并与单纯PTGD组20例(对照组)比较。结果:治疗后两组患者的WBC、NEUT%、TB、DB、CRP均明显下降;两组治疗后ALP、GGT、ALT降低不明显,治疗后组间比较无统计学意义(P>0.05);治疗后两组组间比较CRP差异明显(P<0.05);在降低抗生素使用时间、住院费用方面观察组更为显著(P<0.05)。结论:中药结合介入治疗方法能显著降低急性重症胆囊炎患者WBC、NEUT%、TB、DB、CRP水平,并有效降低患者抗生素使用时间、住院费用。

Objective ： To evaluate the clinical effect of interventional treatment and TCM on the treatment of severe acute cho-lecystitis. Methods ： A total of 20 patients with severe acute cholecystitis were given TCM after PTGD （ the treatment group）. Blood samples were collected before and after the treatment. Blood concentrations of WBC, NEUT% ,TB, DB, ALP, GGT, ALT and CRP were measured. And the records of hospitalization time, days of antibiotic use, hospitalization expenses were made. Comparisons were also made between pretreatment parameters and corresponding post treatment parameter. Results ： Blood concentrations of WBC, NEUT%, TB, DB and CRP all significantly decreased in patients from both groups. After treatment, ALP, GGT and ALT re- duced not obviously, and between treatment groups there was no statistical significance. The observation group showed better effect in decreasing blood concentrations of CRP, and reducing days of antibiotic use and hospitalization expenses （ P 〈 O. 05 ）. Cortclu- sion.TCM with interventional treatment was effective in treating severe acute cholecystitis.