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血清胆红素在冠心病患者中的应用价值研究进展 被引量:2

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摘要 血清胆红素是体内衰老红细胞裂解而释放出的血红蛋白产生的,一直被作为肝胆系统疾病及溶血性疾病的诊断指标。近年来,随着对体内抗氧化物质的广泛研究,许多文献相继报道了胆红素的抗氧化作用[1]。胆红素与白蛋白分子的不对称结合使间接胆红素分子上的氢转化为活性氢原子,加上胆红素分子内的共扼双键系统使间接胆红素具有捕获氧自由基(OFR)的能力。OFR对内皮细胞的损伤在动脉粥样硬化(AS)的发生中起着重要作用。
出处 《天津医科大学学报》 2014年第6期506-508,共3页 Journal of Tianjin Medical University
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  • 1王效增,韩雅玲.冠状动脉介入术后再狭窄的药物防治[J].心血管康复医学杂志,2005,14(2):190-192. 被引量:14
  • 2伍树芝.血清胆红素水平与冠心病关系的探讨[J].心血管康复医学杂志,2006,15(3):260-261. 被引量:15
  • 3Greabu M, Olinescu R,Kummerow FA. et al. The levels of bilirubin may be related to an inflammatory condition in patients with corenary heart disease[ J]. Acta Pol Pharm,2001,58 :2225.
  • 4Takafuni O, Jitsuo H, Mie K, et al. Elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stcnosis:subanalysis of the japanese coronary artery disease (CAD) study[J]. Cite J,2009,73(5) :885.
  • 5Alcaraz M J, Fernandez P, Gufllen MI. Anti-inflammatory actions of the heine oxygenasc-1 pathway [ J ]. Curt Pharm Des, 2003,9 (30) : 2541.
  • 6Naglaa KI, Androw DB, Gregory YHL, et al. Hemoxygenase-1 in cardiovascular disease[J]. JACE,2008 ,52(12) :971.
  • 7Hunt SC,Kronenberg F,John H,et al.Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait:the NHLBI family heart study[J].Atherosclerosis,2001,154(3): 747-754.
  • 8Ishikawa K,Navab M,Leitinger N,et al.Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL[J].J Clin Invest,1997,100(5):1209-1216.
  • 9Hunt SC,Wu LL,Hopkins PN,et al.Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees[J].Arterioscler Thromb Vasc Biol,1996,16(8):912-917.
  • 10Wu TW,Fung KP,Wu J,et al.Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins[J].Biochem Pharmacol,1996,51(6):859-862.

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  • 1Greif M,Arnoldt T,von Ziegler F,et al.Lipoprotein(a)is independently correlated with coronary artery calcification[J].Euro J Internal Med,2013,24(1):75-79.
  • 2Schwertner HA,Jackson WG,Tolan G.Association of low serum concentration of bilirubin with increased risk of coronary artery disease[J].Clinical chemistry,1994,40(1):18-23.
  • 3赵晓琴.胆红素抗氧化作用及其与冠心病关系的研究进展[J].实用心脑肺血管病杂志,2015,23(1):141-143.
  • 4Horsfall LJ,Nazareth I,Petersen I.Cardiovascular events as a function of serum bilirubin levels in a large statin-treated cohort[J].Circulation,2012,126(22):2556-2564.
  • 5Kalkan GY,Gür M,Baykan AO,et al.Serum bilirubin level and aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease[J].Angiology,2013,7(6):316-321.
  • 6Breimer LH,Wannamethee G,Ebrahim S,et al.Serum bilirubin and risk of ischemic heart disease in middle-aged British men[J].Clinical chemistry,1995,41(10):1504-1508.
  • 7Kamstrup PR,Benn M,Tybj?rg-Hansen A,et al.Extreme lipoprotein(a)levels and risk of myocardial infarction in the general population the Copenhagen City Heart Study[J].Circulation,2008,117(2):176-184.
  • 8Maranh?o RC,Carvalho PO,Strunz CC,et al.Lipoprotein(a):structure,pathophysiology and clinical implications[J].Arq Bras Cardiol,2014,103(1):76-84.
  • 9Bengtsson E,To F,Grubb A,et al.Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice[J].Atherosclerosis,2005,180(1):45-53.
  • 10Ganda A,Magnusson M,Yvan-Charvet L,et al.Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis[J].Circulation,2013,127(9):988-996.

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