恶性骨肿瘤患者化疗间歇期睡眠障碍与生活质量的相关性研究

Sleep Disturbance and Quality of Life of Patients with Bone Tumors during Chemotherapy Intermission

目的了解恶性骨肿瘤患者化疗间歇期的睡眠障碍和生活质量情况,以及睡眠障碍与生活质量的相关关系。方法使用匹兹堡睡眠质量指数,欧洲癌症研究与治疗组织生活质量核心问卷对120例在广州市某三级甲等医院进行化疗的骨肿瘤患者进行问卷调查。结果恶性骨肿瘤患者化疗间歇期睡眠障碍评分(8.44±3.67)分,有55.8%的患者存在睡眠障碍。患者生活质量明显低于常模,除认知功能、气促、便秘和腹泻4个条目外,其余两组比较差异有统计学意义(P<0.05),但总体生活质量优于住院患者,除社会功能、便秘和腹泻3个条目外,其余两组比较差异有统计学意义(P<0.05)。生活质量的各功能维度得分与睡眠障碍得分呈负相关(P<0.01),症状维度中,除恶心与呕吐和腹泻外,其余各症状得分与生活质量呈正相关(P<0.01)。结论骨肿瘤患者化疗间歇期生活质量较差,且普遍存在睡眠障碍症状,睡眠障碍越严重,患者生活质量越差。因此提示医护人员要关注患者的睡眠质量,分析导致睡眠障碍的原因,提出干预措施,从而提高化疗患者的生活质量。

Objective To assess the sleep disturbance and quality of life（QOL） in patients with bone tumors during chemotherapy intermission. Methods A total of 120 patients were recruited from a Class III Grade I hospital in Guangzhou in this study. Sleep disturbance and QOL were respectively evaluated by Pittsburgh sleep quality index（PSQI） and European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30（EORTC-QLQ-C30）. Results The mean score of QOL of patients was significantly lower than that of the general population in Asia but higher than that of hospitalized patients（ P0.05）. The mean score of sleep disturbance was 8.44±3.67 and the patients with sleep disturbance had lower scores in function domains but had higher scores in symptom domains（P〈0.05）. Conclusion The quality of life in patients with malignant bone tumors during chemotherapy intermission is poor, and sleep disturbance is prevalent among the patients. There is negative correlation between QOL and sleep disturbance and targeted measures should be implemented to improve patients ＇ QOL.