摘要
目的:系统性评价中西医结合治疗儿童哮喘的临床疗效。方法:采用计算机全面检索中西医结合治疗儿童哮喘随机对照试验的中文文献,检索日期截止至2014年6月6日,由2位研究者独立对纳入研究的文献进行方法学质量评价,并进行资料提取,采用Rev Man4.2软件进行Meta分析。结果:共有9篇文献符合纳入标准,试验覆盖931例患者。Meta分析结果显示中西医结合治疗组的总有效率与单用西医治疗组相比,合并OR=2.88,95%CI为[1.94,4.27],对总体效应进行假设检验得Z值为5.26,P<0.000 01,两者比较差异具有统计学意义(P<0.000 01)。"漏斗图"图形显示不存在发表性偏倚。结论:现有临床证据表明中西医结合治疗儿童哮喘可提高临床疗效,但由于纳入研究质量所限,尚需开展更多高质量的研究进行深入分析。
Objective：To analyze the efficacy of the integrative medicine therapy on childhood asthma by meta-analysis. Methods： Computer comprehensive retrieved literatures in Chinese about randomized controlled trial in treating childhood asthma by the inte- grative medicine, which compared with western medicine. Retrieval date is until 6 Jun, 2014, the study and data was evaluated and extracted independently by two researchers. The data was analyzed by Meta-analysis on Rev Man 4.2 software. Results： 9 litera- tures met the inclusion criteria, included 931 patients. Results of Meta analysis showed： compared with singly western medicine group, the pooled odds ratio （OR） value for the total effect of the group of integrative medicine therapy was 2. 88, 95Y00CI was [-1.94, 4.27]. Overall effect was analyzed, the Z value of hypothesis test was 5.26, P〈0. 00001. there was significant difference between the 2 groups（P〈0. 000 01）. Funnel plots showed that publishing bias no exists. Conclusion：clinic evidences confirmed that clinical effect can be increased in Treating childhood asthma hy the integrative medicine. But due to the limitation of the research quality, more high-quality clinical trials research should be carried out and analyzed deeply.
出处
《亚太传统医药》
2014年第22期74-76,共3页
Asia-Pacific Traditional Medicine
