盆炎消灌肠液对家兔微循环障碍血液流变学的影响

Influence of Penyanxiao Clysis Fluid on Hemorheology in Rabbit Model with Microcirculation Disorder

目的:观察盆炎消灌肠液对家兔微循环障碍模型血液流变学的影响。方法:家兔30只,随机分为5组,即对照组、模型组、盆炎消灌肠液低剂量组(5.0 g/kg)、盆炎消灌肠液高剂量组(10.0 g/kg)和盐酸川芎嗪组,每组6只。采用高分子右旋糖酐建立家兔微循环障碍模型。应用FASCO-300全自动血流变检测仪检测全血黏度和血浆黏度,文氏管法检测红细胞压积,Wintrobe管法检测血沉,并计算其他各项血流变指标。结果:盆炎消灌肠液低剂量组、高剂量组和川芎嗪组均能明显对抗由高分子右旋糖酐造成的微循环障碍,降低全血黏度、血浆黏度和全血还原黏度,降低红细胞聚集和血栓形成,改善红细胞变形指数和压积,与模型组相比差异均有统计学意义(P<0.01),且高剂量组比低剂量组效果更显著(P<0.01)。盆炎消灌肠液低剂量组与川芎嗪组相比,红细胞变形指数改善效果更显著(P<0.01),其他指标差异无统计学意义(P>0.05)。结论:盆炎消灌肠液能明显改善家兔微循环障碍和血液流变学各项指标。

Objective：To observe the effects of Penyanxiao clysis fluid on hemorheology in the rabbit model with microcirculation disorder. Methods：Thirty rabbits were randomly divided into 5 groups as follows,the control group, the model group, the low-dose treatment group（treated with clysis fluid 5.0 g/kg）,the highdose treatment group（treated with clysis fluid 10.0 g/kg） and the Chuanxiongqin group as positive control. The rabbit model was developed with the macromolecule dextran. The blood viscosity and plasma viscosity were tested using the FASCO-300 automatic monitor, HCT was detected by the Venturi method, the blood sedimentation by the Wintrobe method, and the hemorheological index was then calculated. Results：Compared with the model group, two treatment groups had the decreased blood viscosity, plasma viscosity and the whole blood reductive viscosity（P 0.01）. The cell aggregation and thrombosis were reduced, and the erythrocyte deformation index and HCT improved, which suggested the therapeutical effects of Penyanxiao clysis fluid with dose-dependence on the microcirculation disorder induced by macromolecule dextran. The erythrocyte deformation index in the low-dose treatment group was better than that in the Chuanxiongqin group（P〈0.01）.Conclusions：Penyanxiao clysis fluid can significantly improve the microcirculation and hemorheological indexes in the rabbit model with microcirculation disorder.