TNF-α基因G-308A多态性与中国人原发性高血压相关性的Meta分析

Correlation between gene G-308A polymorphism in TNF-α and essential hypertension in Chinese population: a Meta-analysis

目的：评价肿瘤坏死因子α（TNF-α）基因G-308A多态性与中国人原发性高血压（essential hypertension，EH）的相关性。方法计算机检索PubMed、EMbase、CBM、CNKI和万方数据库，收集关于TNF-α基因G-308A多态性与中国人EH相关性的病例-对照研究，检索时限均为建库至2013年9月1日。由2位评价者严格按照纳入与排除标准独立筛选文献、提取资料及质量评价后，采用Stata12.0软件进行Meta分析。采用Egger线性回归法检测发表偏倚。结果最终纳入6个病例-对照研究，包括EH患者1203例和健康对照1354例。Meta分析结果显示：对于中国人群，基因型GA人群的EH发病风险高于基因型GG人群（OR=1.54，95%CI：1.23～1.92，P＜0.001）；基因型AA＋GA人群的EH发病风险高于基因型GG人群（OR=1.59，95%CI：1.28～1.98，P＜0.001）；等位基因A人群的EH发病风险高于等位基因G人群（OR=1.58，95%CI：1.29～1.95，P＜0.001）。结论中国人群TNF-α基因G-308A等位基因A与EH发病有关。受纳入研究数量及质量限制，上述结论尚待开展进一步研究加以验证。

Objective To review the correlation between gene G-308A polymorphism in tumor necrosis factor-α（TNF-α） and essential hypertension （EH） in Chinese population. Methods The databases of PubMed, EMbase, CBM, CNKI and WangFang Database were retrieved with computer for collecting the case-controlled studies about the correlation between gene G-308A polymorphism in TNF-α and EH in Chinese population from establishing time of databases to Sept. 1, 2013. After literature screening rigorously according to inclusion and exclusion criteria, data extracting and quality reviewing by 2 reviewers independently, a Meta-analysis was conducted by using Stata12.0 software. The publication bias was detected by using Egger linear regression. Results There were totally 6 studies included involving 1203 EH cases and 1354 health control cases. The results of Meta-analysis showed that in Chinese population, the risk of EH was higher in population with GA genotype than that in population with GC genotype （OR=1.54, 95%CI：1.23-1.92, P〈0.001）, was higher in population with AA＋GA genotype than that in population with GG genotype （OR=1.59, 95%CI：1.28-1.98, 〈0.001）, and was higher in population with allele A than that in population with allele G （OR=1.58, 95%CI：1.29-1.95, P〈0.001）. Conclusion Allele A of gene G-308A polymorphism in TNF-αis correlated to incidence of EH. The above conclusion requires further studies to identification because of limited quantity and quality in this study.