急性心肌梗死及扩张型心肌病心力衰竭患者血浆NT-proBNP、NT-proCNP水平比较

Comparison in levels of plasma NT-proBNP and NT-proCNP in patients with heart failure induced by acute myocardial infarction and dilated cardiomyopathy

目的：探讨急性心肌梗死（AMI）及扩张型心肌病（DCM）心力衰竭患者血浆N端脑钠肽前体（NT-proBNP）和N端C型利钠尿肽前体（NT-proCNP）水平的差异。方法2012年1月-2012年12月，连续入选心力衰竭的患者117例，其中AMI组、DCM组患者分别为89例及28例，同期健康体检对照组76例，分别检测及比较三组人群血浆NT-proBNP和NT-proCNP的水平及差异。结果健康对照组NT-proBNP水平[（5.8±1.2）pmol/L]明显低于AMI组[（57.6±21.3）pmol/L]（P＜0.05）和DCM组[（51.7±19.8）pmol/L]（P＜0.05），差异统计学意义；AMI组和DCM组NT-proBNP水平无统计学差异（P＞0.05）。健康对照组NT-proCNP水平[（4.1±1.2）pmol/L]低于AMI组[（21.2±4.8）pmol/L]（P＜0.05）和DCM组[（6.9±1.5）pmol/L]（P＜0.05），AMI组NT-proCNP水平明显高于DCM组（P＜0.05），差异统计学意义。结论AMI及DCM心力衰竭患者血浆NT-proBNP水平无明显差异，而NT-proCNP水平有较大差异。

Objective To investigate the difference in levels of plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） and N-terminal pro-C-type natriuretic peptide （NT-proCNP） in patients with heart failure induced by acute myocardial infarction （AMI） and dilated cardiomyopathy （DCM）. Methods The patients with heart failure （n=117） were continuously chosen from Jan. 2012 to Dec. 2012, and divided into AMI group （n=89） and DCM group （n=28）. Other persons with health examinations （n=76） at the same period were chosen as control group. The levels of NT-proBNP and NT-proCNP were detected and compared in 3 groups. Results The level of NT-proBNP was significantly lower in control group [（5.8±1.2） pmol/L] than that in AMI group [（57.6＆#177;21.3 ） pmol/L, P〈0.05] and DCM group [（51.7±19.8） pmol/L, P〈0.05]. The level of NT-proBNP had no statistical difference between AMI group and DCM group （P〉0.05）. The level of NT-proCNP was lower in control group [（4.1±1.2） pmol/L] than that in AMI group [（21.2±4.8） pmol/L, P〈0.05] and DCM group [（6.9±1.5） pmol/L, P〈0.05], and was significantly higher in AMI group than that in DCM group （P〈0.05）. Conclusion The level of NT-proBNP has no significant difference and level of NT-proCNP has difference in patients with heart failure induced by AMI and DCM.