摘要
目的:探讨急性心肌梗死(AMI)及扩张型心肌病(DCM)心力衰竭患者血浆N端脑钠肽前体(NT-proBNP)和N端C型利钠尿肽前体(NT-proCNP)水平的差异。方法2012年1月-2012年12月,连续入选心力衰竭的患者117例,其中AMI组、DCM组患者分别为89例及28例,同期健康体检对照组76例,分别检测及比较三组人群血浆NT-proBNP和NT-proCNP的水平及差异。结果健康对照组NT-proBNP水平[(5.8±1.2)pmol/L]明显低于AMI组[(57.6±21.3)pmol/L](P<0.05)和DCM组[(51.7±19.8)pmol/L](P<0.05),差异统计学意义;AMI组和DCM组NT-proBNP水平无统计学差异(P>0.05)。健康对照组NT-proCNP水平[(4.1±1.2)pmol/L]低于AMI组[(21.2±4.8)pmol/L](P<0.05)和DCM组[(6.9±1.5)pmol/L](P<0.05),AMI组NT-proCNP水平明显高于DCM组(P<0.05),差异统计学意义。结论AMI及DCM心力衰竭患者血浆NT-proBNP水平无明显差异,而NT-proCNP水平有较大差异。
Objective To investigate the difference in levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and N-terminal pro-C-type natriuretic peptide (NT-proCNP) in patients with heart failure induced by acute myocardial infarction (AMI) and dilated cardiomyopathy (DCM). Methods The patients with heart failure (n=117) were continuously chosen from Jan. 2012 to Dec. 2012, and divided into AMI group (n=89) and DCM group (n=28). Other persons with health examinations (n=76) at the same period were chosen as control group. The levels of NT-proBNP and NT-proCNP were detected and compared in 3 groups. Results The level of NT-proBNP was significantly lower in control group [(5.8±1.2) pmol/L] than that in AMI group [(57.6±21.3 ) pmol/L, P〈0.05] and DCM group [(51.7±19.8) pmol/L, P〈0.05]. The level of NT-proBNP had no statistical difference between AMI group and DCM group (P〉0.05). The level of NT-proCNP was lower in control group [(4.1±1.2) pmol/L] than that in AMI group [(21.2±4.8) pmol/L, P〈0.05] and DCM group [(6.9±1.5) pmol/L, P〈0.05], and was significantly higher in AMI group than that in DCM group (P〈0.05). Conclusion The level of NT-proBNP has no significant difference and level of NT-proCNP has difference in patients with heart failure induced by AMI and DCM.
出处
《中国循证心血管医学杂志》
2014年第4期453-454,457,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
急性心肌梗死
扩张型心肌病
N端脑钠肽前体
N端C型利钠尿肽前体
Acute myocardial infarction
Dilated cardiomyopathy
N-terminal pro-brain natriuretic peptide
N-terminal pro-C-type natriuretic peptide