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Nek2与肿瘤及其耐药性研究进展

Research progress of Nek2 in cancers and the drug resistance
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摘要 Nek2是NIMA相关蛋白激酶家族中一个成员,是一种特殊的染色体不稳定(chromosomal instability,CIN)基因,Nek2蛋白是调节有丝分裂进程关键的蛋白,在中心体分离、纺锤体形成和有丝分裂进程中起重要作用。笔者分别从Nek2在肿瘤染色体不稳定、有丝分裂纺锤体组装监控点、中心体分裂和肿瘤耐药性中所起的作用来阐述Nek2与肿瘤的关系。 Nek2is a member of the NIMA-related kinases family,a kind of chromosomal instability gene,and an essential regulator of mitosis,it plays an important role in the centrosome splitting,formation of spindle and mitosis.This review aims to elucidate that Nek2 plays an important role in chromosomal instability,spindle assembly checkpoint,centrosome splitting and drug resistance,then illustrate the relationship between Nek2 and cancers.
作者 王锐 周英琼
机构地区 桂林医学院研究生院 桂林医学院附属医院病理科
出处 《华夏医学》 CAS 2014年第5期131-134,共4页 Acta Medicinae Sinica
关键词 NIMA相关蛋白激酶2 有丝分裂 肿瘤 耐药 Nek2 mitosis cancers drug resistance
分类号 R730.22 [医药卫生—肿瘤]
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参考文献17

  • 1Morris N R.Mitotic mutants of aspergillus nidulans[J].Genet Res,1975,26:237-254.
  • 2Letwin K,Mizzen L,Morro B,et al.A mammalian dual specificityprotein kinase,Nek1,is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells[J].EMBO J,1992,11 (10):3521-3531.
  • 3Lee J,Gollahon L.Nek2-targeted ASO or siRNA pretreatment enhances anticancer drug sensitivity in triple negative breast cancer cells[J].Int J Oncol,2013,42(3):839-847.
  • 4Hayward D G,Clarke R B,Faragher A J,et al.The centrosomat kinase Nek2 displays elevated levels of protein expression in human breast cancer[J].Cancer Res,2004,64(20):7370-7376.
  • 5Rellos P,Ivins F J,Baxter J E,et al.Structure and regulation of the human Nek2 centrosomal kinase[J].J Biol Chem,2007,282(9):6833-6842.
  • 6Hayes M J,Kimata Y,Wattam S L,et al.Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C[J].Nat Cell Biol,2006,8 (6):607-614.
  • 7Zhou W,Yang Y,Xia J,et al.NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers[J].Cancer Cell,2013,23 (1):48-62.
  • 8Mariani L,Chiroli E,Nezi L,et al.Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores[J].Curr Biol,2012,22 (20):1900-1908.
  • 9Choi J W,Kim Y,Lee J H,et al.High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis inurothelial bladder cancer[J].Virchows Arch,2013,463 (5):681-687.
  • 10ConroyP C,Saladino C,Dantas T J,et al.C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis[J].Cell Cycle,2012,11 (20):3769-3778.
华夏医学
2014年 第5期

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