摘要
目的探讨不良孕产史夫妇与染色体核型异常的关系。方法采集不良孕产史夫妇病历资料,并抽取外周血培养,然后进行常规G显带核型分析。结果 8609例不良孕产史夫妇中,共检出异常染色体核型521例,异常率为6.05%。其中随体变异174例,异常率为2.02%,染色体倒位164例,异常率为1.90%;副缢痕的增长15例,异常率为0.17%,平衡易位131例,异常率为1.52%,数目异常37例,异常率为0.43%。核型异常发生率在不同性别中差异无显著性。结论染色体核型异常是导致不良孕产史的重要原因之一,对不良孕产史夫妇双方进行细胞遗传学检查,提供优生咨询,再孕指导与监测,能够有效防止患儿出生,提高出生人口素质。
Objective:To analyze the relationship between abnormal chromosome karyotype and abnormal pregnancy-labor history. Methods:The G-banding Patterns of the Chromosomes in 8609 couples with abnormal pregnancy history were studied by Culture of Peripheral Blood Lymphocytes. Results:521 karyotype abnormalities were detected in 8609 couples,abnomal karyotype rate was 6.05%.Among 521 cases,174 had chromosome satellile varaiations,abnormal rates was 2.02%,164 had inversion,annormal rate was 1.9%,15 had extended secondary constriction,abnormal rate was 0.17%,131 had balanced translocations,abnormal rate was 1.52%,37 had abnormal chromosomenumber,abnormal rate was 0.43%. The abnomal karyotype rate was same between men and women. Conclusion:The karyotype abnormality is one of the important reasons of abnormal pregnancy.Cytogeneticalstudy,eugenic advice,pregnancy guide and monitoring for couples withabnormal pregnancy history is useful to population quality.
出处
《中国优生与遗传杂志》
2014年第11期58-60,共3页
Chinese Journal of Birth Health & Heredity
关键词
不良孕产史
染色体异常
细胞遗传学
Abnormal pregnancy-labor history
Chromosome aberration
Cytogenetics