北京地区8609例不良孕产史夫妇的染色体核型分析

Study on chromosome karyotype of 8609 cases with abnormal pregnancy-labor history

目的探讨不良孕产史夫妇与染色体核型异常的关系。方法采集不良孕产史夫妇病历资料,并抽取外周血培养,然后进行常规G显带核型分析。结果 8609例不良孕产史夫妇中,共检出异常染色体核型521例,异常率为6.05%。其中随体变异174例,异常率为2.02%,染色体倒位164例,异常率为1.90%;副缢痕的增长15例,异常率为0.17%,平衡易位131例,异常率为1.52%,数目异常37例,异常率为0.43%。核型异常发生率在不同性别中差异无显著性。结论染色体核型异常是导致不良孕产史的重要原因之一,对不良孕产史夫妇双方进行细胞遗传学检查,提供优生咨询,再孕指导与监测,能够有效防止患儿出生,提高出生人口素质。

Objective：To analyze the relationship between abnormal chromosome karyotype and abnormal pregnancy-labor history. Methods：The G-banding Patterns of the Chromosomes in 8609 couples with abnormal pregnancy history were studied by Culture of Peripheral Blood Lymphocytes. Results：521 karyotype abnormalities were detected in 8609 couples,abnomal karyotype rate was 6.05%.Among 521 cases,174 had chromosome satellile varaiations,abnormal rates was 2.02%,164 had inversion,annormal rate was 1.9%,15 had extended secondary constriction,abnormal rate was 0.17%,131 had balanced translocations,abnormal rate was 1.52%,37 had abnormal chromosomenumber,abnormal rate was 0.43%. The abnomal karyotype rate was same between men and women. Conclusion：The karyotype abnormality is one of the important reasons of abnormal pregnancy.Cytogeneticalstudy,eugenic advice,pregnancy guide and monitoring for couples withabnormal pregnancy history is useful to population quality.