义乌地区24756例孕中期产前筛查及随访结果分析

An analysis of maternal follow-up results of 24756 cases of prenatal screening in Yiwu city

目的探讨孕中期母血产前筛查在临床中的应用和意义。方法应用时间分辨荧光免疫分析法检测孕中期孕妇血清中甲胎蛋白(AFP)、游离绒毛膜促性腺激素(Free-h CG)、未结合雌三醇(u E3)水平,用专用风险分析软件进行数据计算分析,对筛查出的高风险孕妇经优生遗传咨询,行羊水穿刺和产前超声检查。结果 24 756例孕妇中检出各类高风险人群共1491例,筛查阳性率6.02%;高风险孕妇中羊水穿刺率70.42%,妊娠结局随访率100%,胎儿异常发生率1.81%;低风险孕妇妊娠结局随访率96.05%,胎儿异常发生率0.42%。结论通过孕中期产前筛查和产前诊断,可减少缺陷儿的出生,加强随访能够更好的指导优生工作。

Objective：To explore clinical application and significance of prenatal screening. Methods：Time-resolved fluorescence immunoassay was employed to detect the maternal serum levels of AFP,f-h CG and u E3. We evaluated the risk assessment with assessment software. The pregnant women found with high risk in screening by eugenic genetic counseling were examined by amniocentesis and prenatal ultrasound. Results：Of the 24 756 pregnant women through prenatal screening,1491 were found to have high risk,the positivity rate was 6.02%;the amniotic fluid puncture rate was 70.42%,pregnancy outcome followup rate was 100%,the incidence of abnormal fetus was 1.81%;low risk pregnancy outcome follow-up rate was 96.05%,the incidence of abnormal fetus was 0.42%. Conclusion：Prenatal screening can improve the detection rate of the infants with congenital defects,which is an effective measure to improve the quality of birth population.