老年支气管哮喘患者接受小剂量糖皮质激素联合茶碱的疗效分析

Clinical Analysis of Small Dose of Gucocorticoids Combined with Theophylline in Treating Elderly Patients with Bronchial Asthma

目的探讨小剂量糖皮质激素联合茶碱治疗老年支气管哮喘的临床效果和安全性.方法选择昆明市第一人民医院2011年1月至2013年12月收治的老年支气管哮喘患者68例,随机数字法分为2组,各34例,所有患者均给予小剂量二丙酸倍氯米松吸入治疗,观察组增加给予茶碱治疗.结果 2组患者治疗后各项临床指标均改善,其中观察组在FEV1%、PEFR和嗜酸性粒细胞百分比方面优于对照组(P<0.05),2组总有效率分别为97.1%和85.3%,观察组优于对照组(P<0.05),均未见明显不良反应.结论小剂量糖皮质激素联合茶碱治疗老年支气管哮喘临床效果显著,可有效改善患者肺功能,且安全,适宜于老年哮喘患者的治疗.

Objective To investigate the effect and safety of small dose of gucocorticoids combined with theophylline in treating elderly patients with bronchial asthma. Methods 68 elderly patients with bronchial asthma admitted in our hospital from 2011 to 2013 were divided into two groups by randomly number methods and each for34, all were treated with small dose of gucocorticoids,patients in observation group were also given theophylline.Results All the indexex were improved after treatment, and the FEV1%, PEFR and percentage of eosinophils of observation group were better than those of control group（P〈0.05）, the total efficiency rate of two groups were97.1% and 85.3% respectively（P〈0.05）, and there was no obvious adverse reactions. Conclusion Small dose of gucocorticoids combined with theophylline has good effect and high safety in treating elderly patients with bronchial asthma, it can significantly improve the lung function of patients,and fit for the treatment of elderly patients with bronchial asthma.