胃癌患者外周血血小板膜糖蛋白水平变化及影响因素分析

The Changes of Platelet Membrane Glycoprotein Levels in Peripheral Blood of Patients with Gastric Cancer and Its Influencing Factors

目的探讨胃癌患者外周血血小板膜糖蛋白水平变化及其影响因素的临床意义.方法采用流式细胞术(flow cytometry,FCM)检测87例胃癌患者和40例健康体检者外周血血小板膜糖蛋白CD62p、CD63水平,并作对比分析.结果胃癌患者外周血血小板膜糖蛋白CD62p(4.15±1.42)%、CD63(4.72±1.54)%水平明显高于健康体检者CD62p(1.54±0.44)%、CD63(1.23±0.34)%,2者间差异有统计学意义(P<0.01).胃癌患者外周血血小板膜糖蛋白水平变化分别受临床分期CD62p、CD63分别为[(2.80±0.63)、(4.76±1.25)、(3.28±0.70)(5.36±1.37)]、手术与否CD62p、CD63分别为[(3.49±1.21)、(4.86±1.28)、(3.98±1.31)(5.51±1.38)]及肿瘤转移与否CD62p、CD63分别为[(4.94±1.07)、(3.31±1.25)、(5.55±1.19)、(3.82±1.38)]等因素的影响,而不受性别及病理类型的影响.结论监测外周血血小板膜糖蛋白水平可成为胃癌患者病情进展和预后观察的动态指标.

Objective To explore the clinical significance of the changes of platelet membrane glycoprotein levels in peripheral blood of patients with gastric cancer and its influencing factors. Methods The levels of platelet membrane glycoproteins（CD62p and CD63） in peripheral blood of 87 patients with gastric cancer were measured by flow cytometry（FCM）. 40 healthy people were served as control. Statistical analysis was performed by using the SPSS 10.0 software package.Results The levels of platelet membrane glycoproteins in peripheral blood in patients with gastric cancer [CD62p：（4.15±1.42） % and CD63（4.72±1.54） %] were significantly higher than controls [CD62p（1.54±0.44） % and CD63（1.23±0.34） % ] P0.01. The levels of platelets membrane glycoproteins in peripheral blood in patients with gastric cancer were significantly associated with clinical stage[CD62p（2.80 ±0.63） versus（4.76 ±1.25）; CD63（3.28 ±0.70） versus（5.36 ±1.37）], operation[（CD62p：3.49±1.21） versus（4.86±1.28）、（3.98±1.31） versus（5.51±1.38）],metastasis [CD62p（4.94±1.07） versus（3.31±1.25）;CD63（5.55±1.19） versus（3.82±1.38）],while were not influenced by gender and pathological types. Conclusion Detecting the levels of platelets membrane glycoprotein in peripheral blood may dynamically monitor the progression and prognosis of gastric cancer.