关注糖尿病视网膜病变的信号通路研究 指导糖尿病视网膜病变的靶向治疗

Focusing on the signal pathway of diabetic retinopathy and guiding the target therapy of diabetic retinopathy

糖尿病视网膜病变（DR）是糖尿病患者视力损害的主要原因.近年来,DR相关信号通路的研究更好地揭示了DR的发病机制,为DR的临床治疗研究提供了新的思路,为开发靶向治疗的药物提供了理论依据.阐明生物信号通路在DR发生和发展中的生物学功能,有助于临床医师正确进行医疗决策,选择性、针对性地对其进行干预,大大改善DR的治疗效果.如何在医疗实践中将信号通路的研究和靶向治疗结合起来是推进DR治疗的重要环节.因此我们应注重转化医学研究,重视信号通路研究对靶向治疗的引导作用,使医学基础研究与临床应用研究有机结合起来.

Diabetic retinopathy （DR） is one of common causes of vision loss.Recent years,progress has been made on the signal pathway in DR which provides more theoretical basis for clinical therapies and more chance for developing targeted therapeutic drugs.Understanding the biological function of the signal pathway in DR is helpful for physicians to selectively control its biological activities,make medical decisions and optimize new approaches to the treatment of DR.How to closely combine the study of signal pathway and targeted therapy in practice is a key link of improving the therapeutic effect of DR.Therefore,we should pay attention to translational medicine and reinforce targeted therapy in DR.