氢气眼科医学研究进展

Hydrogen research in ophthalmology

氧化应激与眼科多种疾病的发生、发展密切相关.近来研究发现,氢气是一种选择性的抗氧化物质,在治疗和预防多种疾病,如视网膜新生血管病变、糖尿病视网膜病变、视网膜缺血-再灌注损伤、化学烧伤及光损伤等方面都有所应用.氢气还具有相对分子质量小、水溶性和脂溶性良好、可通过自由扩散穿透细胞膜到达线粒体等靶向细胞器的优势.就氢气在眼科医学领域的研究进展及氢气的给药方式等进行综述.

Oxidative stress is thought to be associated with many common ophthalmic diseases.Recently studies showed that hydrogen is an antioxidant,and it can selectively reduce the hydroxyl radicals and therefore is used to the prevention and treatment of many diseases,such as retinal neovascularization disease,diabetic retinopathy,retinal ischemia-reperfusion injury,retinal light-injury,etc.Also,hydrogen has a small molecular weight and good water-and lipid-solubility,so it can diffuse freely through the cell membrane toward organelles like mitochondria to exert its treating effect.The research progresses in the application of hydrogen in ophthalmology were summarized.