通天草水提物对阿尔茨海默病小鼠海马白介素-1β水平的影响

Effects of aqueous extract from waternut herb on Interleukin-1β of Hippocampal in Alzheimer's disease mice

将雄性小鼠随机分成对照组、模型组、吡拉西坦组(0.62g·kg-1·d-1)、AEWH高剂量组(2.0g·kg-1·d-1)、AEWH低剂量组(0.5g·kg-1·d-1)。采用Aβ1-42小鼠双侧脑室注射诱导AD模型小鼠。小鼠给予AEWH灌胃,连续治疗18d后取材,采用双抗体夹心法测定海马IL-1β水平。与对照组比较,模型组小鼠海马IL-1β水平明显升高(P<0.05);与模型组比较,AEWH高剂量组海马IL-1β水平明显降低(P<0.05)。说明AEWH高剂量(2.0g·kg-1·d-1)能降低IL-1β水平,AEWH通过抑制IL-1β在AD治疗中发挥重要作用。

Male mice were randomly divided into control group, model group, piracetam group ＋（0.62g · kg^-1· d^-1）, AEWH high dose group （2.0g ·kg^-1· d^-1）, AEWH low dose group （0.5g ·kg^-1·d^-1）. A β 1-42 injected mice using two-ventricle induced mouse model of AD. AEWH mice were given orally, 18d drawn after continuous treatment, hippocampal IL-1β levels measured by double antibody sandwich assay. Compared with the control group, model group mouse hippocampal IL-1 β levels were significantly increased （P 〈0.05）. Compared with the model group, AEWH high dose group of hippocampal IL-1β levels were significantly lower （P 〈0.05）. Description AEWH high dose （2.0g· kg^-1 · d^-1） reduces IL-1β levels, AEWH by inhibiting IL-1β play an important role in the treatment of AD.