丹参素冰片酯合成的工艺过程

Danshensu bornyl synthesis process

在现代药物研发中,经常采用天然开发、药物合成提纯、副作用转变法等手段。丹参素是易溶于水的一种酸。在科学家们近十几年的研究和不断创新下,发现3,4-二烃基苯丙酮酸在乳酸脱氧酶及辅助因子NADH和FDH存在下可以生成丹参素,同时发现,左旋多巴在酶催化下生成3,4-二烃基苯丙酮酸,即将左旋多巴在室温下经70%水合(CF3CO)20处理后水解得到。在合成丹参素冰片酯时,要注意清洁生产,做好防护措施,减少合成过程中产生的有毒物质和含量。

In modern drug development, often using natural means of development, purification of synthetic drugs, side effects, such as changes in law. Danshensu is an acid soluble in water. In nearly 10 years of research on scientists and innovation, the discovery of 3,4 dihydrocarbyltin phenylketonuria in lactate dehydrogenase enzyme cofactors NADH and FDH presence can generate Danshensu, also found that L-dopa in the enzyme-catalyzed under generated phenylpyruvic acid 3,4-dihydrocarbyl, levodopa is about 70% at ambient conditions after hydration （CF3CO） 20 treated hydrolyzed. In the synthesis of Danshensu bornyl, pay attention to clean production, good protective measures to reduce the content of toxic substances and produced during synthesis.