SD-OCT对特发性黄斑裂孔患者对侧眼中心凹组织形态的观察(英文)

Foveal anatomical configuration in fellow eyes of patients with idiopathic macular hole by spectral-domain optical coherence tomography (the FAC study)

目的:通过频域光学相干断层扫描(spectral-domain optical coherence tomography,SD-OCT)观测特发性黄斑裂孔患者对侧眼中心凹的形态结构变化。方法:将50例50眼研究对象分为两组:组1为25例特发性黄斑裂孔患者,组2为25位健康人(对照组)。使用RTVue 100(Optovue,Inc.,Fremont,CA,USA)的"交叉十字"SD-OCT扫描模式,对所有研究对象进行黄斑中心凹广域B型方向扫描。通过卡尺工具测量二维横断面图上中心凹的形态面积。结果:组1中心凹形态面积为0.159±0.03mm2,组2为0.079±0.01mm2。两组比较,差异有统计学意义(P<0.001)。组1中有1例患者对侧眼产生黄斑裂孔。结论:同健康人相比,特发性黄斑裂孔患者的对侧眼中心凹形态有增大趋势。该发现结合其他的一些玻璃体黄斑的致病因素,可能导致特发性黄斑裂孔。

AIM：To evaluate anatomic foveal configuration changes in fellow eyes of patients with idiopathic macular hole using spectral-domain optical coherence tomography （ SD-OCT） . METHODS： Fifty eyes of fifty patients were studied and divided in two groups： group 1 = 25 patients with idiopathic macular hole and group 2 = 25 healthy individuals （control group）. SD-OCT cross line scans were obtained using RTVue 100 （Optovue, Inc., Fremont, CA, USA）. The widest foveal B-scan was selected on each patient. Bidimensional foveal configuration was measured in mm2 using caliper tool. RESULTS：The mean foveal configuration in group 1 was 0. 159 ±0.03mm2 and in group 2 was 0. 079 ±0.01 mm2. The difference between the two groups was statistically significantly （P〈0.001）. In group 1, one patient developed a macular hole in the fellow eye. CONCLUSION： Fellow eyes of patients with idiopathic macular hole tend to have an enlarged foveal configuration when compared to healthy subjects. Our finding combined with other vitreomacular risk factors may play a role in idiopathic macular hole formation.