原花青素在眼科应用的研究进展

Research progress of proanthocyanidins in ophthalmic applications

原花青素是一种广泛存在于自然界植物中的多酚化合物。它具有极强的抗氧化活性和自由基清除能力,并且具有高效、低毒和高生物利用率等优点,可起到降血压、降血脂、抗炎、抗肿瘤、抗衰老、抗疲劳以及预防心脑血管疾病等功效。本文综述了原花青素的理化性质、药理作用、毒理作用及其在眼科应用的最新研究进展,主要是在角膜病、白内障、青光眼、葡萄膜炎、视网膜病变、视神经病变、眼外伤及视疲劳等方面进行概述。相信在不久的将来能对其药物作用机制进一步阐明,发挥其更大的医用价值,为眼科临床应用提供更多经济且有效的药物。

Proanthocyanidins is an effective antioxidants and free radical scavenger derived from kinds of plants in nature. It has some advantages that high absorptivity and bioactivity, low toxicity, which contain broad pharmacological functions such as dropping high blood pressure, reducing blood fat, anti-inflammatory, anti-cancer, anti - aging, anti - fatigue and preventing cardiovascular and cerebrovascular diseases. In this paper, we summarized its physicochemical properties, pharmacologic action and the ophthalmological studies which mainly in keratopathy, cataract, glaucoma, uveitis, retinopathy, traumatic optic neuropathy and asthenopia. With the deeper research and more unequivocal in the pharmacological mechanism of proanthocyanidins, it should make the most of its values in medicine. And some more economical and effective drugs are expected to be provided for the clinical ophthalmology in the near future.