单眼斜视性弱视患者黄斑神经节细胞复合体厚度分析

Analysis the macular ganglion cell complex thickness in monocular strabismic amblyopia patients by Fourier-domain OCT

目的:通过检测单眼斜视性弱视患者双眼黄斑区视网膜神经节细胞复合体厚度,探讨弱视的程度与视网膜神经节细胞厚度的相关性,以及斜视性弱视患者黄斑区神经节细胞复合体结构是否存在异常。方法:选取临床单眼斜视性弱视患者26例52眼。采用美国傅立叶域光学相干断层扫描仪(fourier-domain optical coherence tomography,FD-OCT)iVue同时检测双眼黄斑区神经节细胞复合体厚度,并比较黄斑区神经节细胞复合体厚度与患者最佳矫正视力的相关性。结果:黄斑区神经节细胞复合体厚度(macular ganglion cell complex,mGCC)分为三个区域测量:中心区、内圈(3mm)区、外圈(6mm)区。在斜视性弱视的眼(strabismic amblyopia eye,SAE)测量结果分别是50.74±21.51,101.4±8.51,114.2±9.455μm;在对侧对照眼(contralateral sound eyes,CSE)测量结果分别是43.79±11.92,92.47±25.01,113.3±12.88μm。斜视性弱视眼的黄斑区视神经节细胞复合体厚度与对侧眼相比无显著差异(P>0.05)。最佳矫正视力与黄斑区神经节细胞复合体厚度有相关性,视力矫正越好弱视程度越低的黄斑区神经节细胞复合体厚度相对增厚,黄斑区下方区域的神经节细胞复合体厚度与视力矫正的相关性优于上方。结论:黄斑中心区神经节细胞复合体厚度与弱视矫正视力之间有相关性,虽然mGCC厚度在SAE和CSE无显著差异,但测量mGCC厚度对了解弱视程度有临床意义。

AIM： To detect the macular ganglion cell complex thickness in monocular strabismus amblyopia patients, in order to explore the relationship between the degree of amblyopia and retinal ganglion cell complex thickness, and found out whether there is abnormal macular ganglion cell structure in strabismic amblyopia.METHODS： Using a fourier-domain optical coherence tomography （ FD-OCT） instrument iVue（ Optovue Inc, Fremont, CA）, Macular ganglion cell complex （mGCC） thickness was measured and statistical the relation rate with the best vision acuity correction was compared Gman among 26 patients （ 52 eyes ） included in this study. RESULTS. The mean thickness of the mGCC in macular was investigated into three parts： centrial, inner circle （3mm） and outer circle （6ram）. The mean thicknesses of mGCC in central, inner and outer circle was 50.74± 21.51μm, 101. 4± 8. 51μm, 114. 2± 9. 455μm in the strabismic amblyopia eyes （ SAE）, and 43.79± 11. 92μm, 92.47± 25. 01μm, 113. 3 ±12. 88μm in the contralateralsound eyes （ CSE ） respectively. There was no statistically significant difference among the eyes （P〉 0.05）. But the best corrected vision acuity had a good correlation rate between rnGcc thicknesses, which was better relative for the lower part than the upper part. CONCLUSION. There is a relationship between the amblyopia vision acuity and the mGCC thickness. Although there has not statistically significant difference of the mGCC thickness compared with the SAE and CSE. To measure the macular center mGCC thickness in clinic may understand the deqree of amblvopia.