几种炎症因子与慢性荨麻疹的相关性

Systemic inflammatory factors and chronic urticaria

目的:明确几种炎症因子与慢性荨麻疹(CU)的相关性。方法:采用ELISA法检测40例CU患者以及40名正常对照者血浆C5a水平以及血清C3、C4、ESR、抗溶血性链球菌O(ASO)、C-反应蛋白(CRP)、类风湿因子(RF)水平,分析其与CU症状评分的相关性。结果:与正常对照者比较,CU患者血浆C5a水平以及血清C4水平明显升高(P<0.01),而血清C3水平无统计学差异(P>0.05);患者ESR以及CRP水平明显升高(P<0.01和P<0.05);血清ASO以及RF水平无统计学差异(P>0.05)。CU患者的ESR以及CRP水平与症状评分相关(P<0.01)。结论:慢性荨麻疹患者中存在补体激活和系统性炎症反应。

Objective：To determine the correlation between systemic inflammatory factors and chronic urticaria.Methods：The plasma levels of C5a,serum levels of C3 and C4,erythrocyte sedimentation rate （ESR）,antistreptolysin O （ASO）,rheumatoid factors （RF） and C-reactive protein （CRP） were measured in 40 patients with chronic urticaria and 40 controls.The symptom scores and the levels of the inflammatory factors were correlated.Results：Plasma concentration of C5a and the serum level of C4 was higher in CU patients than in healthy controls （P＜0.01）.There was no significant difference in the level of C3 between the CU group and the control group.The serum levels of ESR and CRP were also significantly higher in CU patients than in controls,and had a significant correlation with clinical symptom scores.Conclusion：Activation of complement and systemic inflammation were present in CU.