Ⅳ期非小细胞肺癌患者生存状况及预后因素分析

The analysis of survival situation and prognostic factors of stage Ⅳ non- small cell lung cancer( NSCLC) patients

目的:探讨Ⅳ期非小细胞肺癌患者生存状况及预后的相关因素。方法:回顾性分析本院2004年10月-2012年3月107例Ⅳ期非小细胞肺癌患者的临床资料。利用Kaplan-Meier法进行生存率统计,并进行Log-rank时序检验,利用比例风险模型(Cox模型)进行多因素分析,筛选出相关因素。结果:Ⅳ期非小细胞肺癌患者1、2、3、5年生存率分别为64.5%、24.3%、12.1%和1.8%,中位生存时间为12.5个月。单因素分析结果显示,患者的KPS评分、组织学类型、靶向治疗、化疗周期大于2个、原发病灶控制情况对生存期有影响(P<0.05)。多因素分析显示,KPS评分、原发灶已控是预后的独立因素(P<0.05)。结论:KPS≥70分、原发灶已控是Ⅳ期非小细胞肺癌患者的独立预后因素,这些患者的生存期较长,是潜在的治疗获益者。

Objective： To study the survival situation and prognostic factors of the stage Ⅳ NSCLC patients. Methods： The clinical data of 107 stage Ⅳ NSCLC patients in our hospital from October 2004 to March 2012 were retrospectively reviewed. The multivariate analysis was performed with Cox proportion risk model. Survival analysis was compared with Kaplan- Meier method and Log- rank test was used. Results： Of all 107 patients the median survival was 12. 5 months,and the 1- year,2- year,3- year and 5- year survival rates were 64. 5%,24. 3%,12. 1%and 1. 8% respectively. The univariate analysis showed that patients＇ KPS score,histological types,target therapy,over2 cycles chemotherapy and the control of primary tumor were related to survival period. The multivariate analysis indicated that patients＇ KPS score,the control of primary tumor were closely related to prognosis. Conclusion： The patients with KPS score≥70 and the primary tumor controled have longer survival time and they can benefit from treatments.