食管鳞癌淋巴管分布及密度与淋巴结转移的关系

The density and disperse in squamous cell carcinoma of esophagus and its relation with lymph node metastasis

目的:探讨食管鳞状细胞癌组织中淋巴管的分布及密度并分析其与淋巴结转移的关系。方法:应用单克隆抗体D2-40检测食管癌巢周围和癌巢中心区以及正常食管组织中淋巴管密度(LVD),分析其与临床病理因素的关系。结果:癌巢周围区LVD明显高于中心区和正常组织(P<0.01)。癌巢周围区LVD与淋巴结转移及分化程度相关(P<0.05),与浸润深度无关(P>0.05),癌巢中心区LVD与食管鳞癌分化程度、浸润深度和淋巴结转移均无相关性(P>0.05)。结论:D2-40是淋巴管特异和敏感的标记物,食管癌功能性淋巴管主要存在于食管癌巢周围,检测癌巢周围淋巴管可能是预测淋巴结转移的可靠指标。

Objective： To investigate the density and disperse significance of the lymphatic in squamous cell carcinoma of the esophagus and its relation with lymph node metastasis. Methods： Monoclonal antibody D2- 40 was used immunohistochemically to detect the lymphatic vessel density（ LVD） in the intra and peri- tumoral areas and normal tissue of the esophagus. Results： LVD of the peri- tumoral area was significantly higher than intra- tumoral area and nomal tissue（ P 0. 01）. LVD of the peri- tumoral area was significantly associated with lymph node metastasis and differentiation（ P 0. 05）,not associated with invasion of the tumor（ P 0. 05）. LVD of the intra- tumoral area was not correlated with the differentiaton,invasion and the lymph node（ P 0. 05）. Conclusion： D2- 40 is sensitive and special marker of lymphatic vessel. LVD of peri- tumoral area is functional. Detection of LVD in peri- tumoral area can be used for prediction of lymphnode metastasis.