大肠癌化疗后脂肪肝的临床研究

Clinical analysis of fatty liver caused by colorectal cancer chemotherapy

目的:研究大肠癌患者化疗后脂肪肝的发生率及其危险因素。方法:分析270例大肠癌患者化疗前后肝脏CT表现及实验室生化指标(AST、ALT、ALP、GGT、TG、CHOL、HDL、LDL)的变化。结果:化疗3个月、6个月及1年后,发生脂肪肝的例数分别为21例(7.8%)、64例(23.7%)、58例(21.5%),化疗后患者肝功能指标及血脂水平较化疗前均有不同程度的升高,差异具有统计学意义(P<0.05,除外高密度脂蛋白),脂肪肝组转氨酶及血脂水平均比非脂肪肝组高,差异具有统计学意义(P<0.05,除外胆固醇)。结论:大肠癌患者化疗后可以发生脂质代谢异常,导致肝脏的脂肪性病变,部分发展为脂肪肝。

Objective： To investigate the incidence and risk factors of post- chemotherapy fatty liver. Methods： To analyze the changes of liver CT and laboratory biochemical indicators（ AST,ALT,ALP,GGT,TG,CHOL,HDL,LDL）of 270 cases before and after chemotherapy. Results： The occurrences of fatty liver were 21（ 7. 8%）,64（ 23. 7%）,58（ 21. 5%） in 3 months,6 months and 1 year after chemotherapy. The laboratory biochemical indicators had different degrees of raises and showed significant difference before and after chemotherapy（ P 0. 05,except HDL）. The laboratory biochemical indicators of fatty liver group were higher than non- fatty liver group with significant difference（ P 0. 05,except cholesterol）. Conclusion： The patients of colorectal cancer can have abnormal fat metabolism after chemotherapy and cause liver fatty change,and part of them can develop to fatty liver.