多器官受侵犯的浆母细胞淋巴瘤1例报告并文献复习

Treatment of plasmablastic lymphoma with multiple organ involvement: A case report and literature review

目的:报道多器官受侵犯的浆母细胞淋巴瘤(PBL)1例探讨PBL的诊治。方法:总结1例多器官受侵犯的PBL临床资料及诊疗过程,并复习国内外文献。结果:女性,50岁,因发热伴右乳腺旁包块起病,持续高热,PET/CT检测提示出现鼻咽部、全身多发淋巴结肿大、肝脾脏的多脏器广泛受侵,经乳腺包块病理检查确诊为PBL,HIV阴性,而EBER阳性。根据Ann Arbor分期该病人为IV期b型,经过3个疗程CHOP+E化疗达到缓解。结论:PBL依据病理学检查确诊,没有标准治疗方案,早诊断和早治疗和预后分子的检测与预后密切相关。

Objective： To assess the pathology diagnosis and prognosis of plasmablastic lymphoma（ PBL）. Methods： One case of PBL with abnormal function of multiple organs was reposed with review of literature. Results： A female patient was admitted with a mass in her right breast and a persistent fever. Imaging by computed tomography and positron emission tomography indicated that the lesion had spread to multiple organs. Pathological result confirmed that the patient had plasmablastic lymphoma with positive Epstein- Barr virus and negative HIV. This patient was IV phase（ B type）. After 3 rounds of CHOP ＋ E chemotherapy,the patient achieved complete remission. Conclusion：Diagnosis of PBL still depends on both clinical and pathological findings. At present there is no standard therapy. The molecules detection,early diagnosis and early treatment was closely related to prognosis of PBL.