INTRABEAM实施乳腺癌术中放疗系统临床应用观察(附20例报告)

Clinical evaluation of the INTRABEAM intraoperative radiotherapy system in 20 patients with breast cancer

目的:评价INTRABEAM术中放射治疗系统临床应用的安全性和优势。方法:INTRABEAM对20例保乳手术患者实施术中瘤床放疗,均为单次照射每次20Gy,施用器规格为4.5cm(范围1.5-5.0cm),治疗持续时间35.5-51分钟。结果:术中照射治疗后有3例发生治疗区局部积液,经抽吸并加压包扎后愈合,乳房水肿1例。结论:INTRABEAM术中放射治疗系统近期无明显毒副作用,INTRABEAM术中放射治疗系统是一项安全良好耐受性技术,病人乐于接受。

Objective： To evaluate of the safety and efficacy of intraoperative radiotherapy（ IORT） with INTRABEAM system during breast- conserving surgery. Methods： A total of 20 patients were treated with IORT 20 Gy /50 k V X- rays. INTRABEAM was used to the tumor bed during breast- conserving surgery. Spherical applicator ranging from 1. 5 to 5. 0cm in diameter was placed inside the tumor cavity. Median treatment time was 20min（ range,35. 5-51）. Results： IORT of the tumor bed during breast- conserving surgery was well tolerated. three patients had accumulating fluid in the tumor cavity and delayed healing of the puncture wound. One patient had breast edema. Conclusion： After IORT of the breast with INTRABEAM system,no unexpected toxicity rates were observed. IORT is safe and well- toerable technique.