新疆维汉妇女宫颈病变组织中CD147、Ki-67的表达及意义

Expression of CD147 and Ki-67 in different cervical lesions between Uygur and Han women in Xinjiang China

目的:探讨新疆维汉妇女宫颈病变及癌变组织中CD147和Ki-67的表达及意义。方法:选择兰州军区乌鲁木齐总医院病理科2008年2月至2012年3月存档的石蜡标本240例,维汉各120例,分为非瘤变组(正常及慢性炎症)、宫颈上皮内瘤变(CIN)Ⅰ组、CINⅡ-Ⅲ组和宫颈鳞癌组各30例,应用免疫组织化学方法检测各组宫颈病变组织中CD147和Ki-67的表达。结果:CD147和Ki-67在维汉族妇女宫颈病变组织中的表达差异无统计学意义(χ2=0.018,P=0.895;χ2=0.071,P=0.79);不同程度宫颈病变组之间CD147和Ki-67的表达差异有统计学意义(χ2=78.841,P=0.000;χ2=124.942,P=0.000),在CINⅡ-Ⅲ组和宫颈鳞癌组CD147和Ki-67的表达差异均无统计学意义(χ2=1.319,P=0.251;χ2=3.339,P=0.068)。结论:CD147和Ki-67在新疆维汉妇女宫颈病变的表达不存在民族差异;CD147和Ki-67的表达与宫颈病变及其癌变的发生发展关系密切。

Objective： To stady the expression and significance of CD147 and Ki- 67 between Uygur and Han women with cervical lesions and cervical carcinoma in Xinjiang. Methods： All 240 Paraffin- embedded cervical lesions and cervical carcinoma specimens were collected from Department of Pathology,Urumqi General Hospital of Lanzhou Military Region between 2008 and 2012,120 cases Uygur women and 120 cases Han women were divided into four groups： non- neoplasia group（ normal and chronic inflammatory group）,cervical intraepithelial neoplasias（ CIN） Ⅰ group,CINⅡ- Ⅲ group and cervical squamous cell carcinoma group. CD147 and Ki- 67 expression were performed by immunohistochemistry. Results： There was no significant difference in the expression of CD147 and Ki-67 between Uygur and Han women（ χ^2= 0. 018,P = 0. 895; χ^2= 0. 071,P = 0. 79）; In the different degree of cervical lesions,the expression of CD147 and Ki- 67 had a significant difference between different groups（ χ^2= 78. 841,P =0. 000; χ^2= 124. 942,P = 0. 000）,except the contrast of CIN Ⅱ- Ⅲ group and cervical squamous cell carcinoma group（ χ^2= 1. 319,P = 0. 251; χ^2= 3. 339,P = 0. 068）. Conclusion： There is no ethnic difference of the expression of CD147 and Ki- 67 between Uygur and Han women with cervical lesions or cervical carcinoma in Xinjiang. CD147 and Ki- 67 had a close association with the occurrence and development of cervical lesions and cervical carcinoma.