纳米载体传递抗肿瘤药物在肿瘤微环境的靶向性及应用研究进展

Research progress and application of nanometer carrier transmission anticancer drugs targeted the tumor microenvironment

大部分传统的化疗药物由于在体内的非特异性分布而导致全身性毒性及许多相关的副作用。近年来,新兴的纳米技术克服了传统药物的非特异性靶向,而且为解决非选择性损伤机体组织的瓶颈问题提供了可能。近年来,越来越多的研究致力于从肿瘤微环境的角度遏制肿瘤的发展,针对肿瘤和微环境的纳米技术也有了快速发展,本文主要对肿瘤的微环境和纳米载体药物传递系统在肿瘤微环境方面的靶向性及应用进行综述,为纳米技术在肿瘤方面的研究提供参考和新的研究思路。

Most of conventional chemotherapeutic drugs have systemic toxicity and many side effects because of their non- specific in vivo distribution. In recent years,emerging nanotechnology has overcome the non- specific targeting of traditional medicines. Recent years,more and more researches which contain tumor progression from the perspective of the tumor microenvironment have been carrier out. The anotechnology has also been developed rapidly in tumor and microenvironment. We mainly discusses the nanocarriers drug delivery system targeting tumor microenvironment and its application in the tumor microenvironment aspects. Nanotechnology can provide a reference and the new aspects for the study in cancer researches.