急性脑梗死患者颈动脉粥样硬化斑块稳定性与D-二聚体浓度变化的相关性

Correlaption between the stability of carotid atherosclerotic plaques and the concentration of D-dimer in acute cerebral infraction patients

目的:探讨脑梗死患者颈动脉粥样硬化斑块稳定性与D-二聚体浓度变化的相关性。方法:收集136例急性脑梗死患者,应用彩色多普勒超声检测急性脑梗死患者颈动脉内-中膜厚度(intima-media thickness,IMT)及粥样硬化斑块性质;采用免疫比浊法测定D-二聚体的浓度,并加以分析评价。结果:不稳定斑块组D-二聚体浓度明显高于稳定斑块组及无斑块组,差异有统计学意义(P<0.05);稳定斑块组D-二聚体浓度明显高于无斑块组,差异有统计学意义(P<0.05)。结论:脑梗死患者颈动脉粥样硬化斑块稳定性与D-二聚体的浓度变化具有相关性,为及时采取防治措施提供了依据。

Objective： To explore the correlation between the stability of carotid atherosclerotic plaques and the concentration of D-dimer in acute cerebral infraction patients. Methods The intima-media thickness （IMT） of carotid and the nature of carotid atherosclerotic plaques were evaluated by color Doppler ultrasonorgraphy in 136 cases of acute cerebral infraction. Furthermore,the concentration of D-dimer were determined by immunoturbidimetry. Rcsults..The concentration of D-dimer in unstableplaques group were obviously increased than those in stable-plaques group,which was a statistical significance（P〈0.05）. The concentration of D-dimer in stable-plaques group were obviously increased than those in no-plaques group,which was a statistical significance（P〈0.05）. Conclusion The stability of carotid atherosclerotic plaques were relative to the concentration of D-dimer in Datienes of acute cerebral infarction,which may be an useful ultrasonic preventive index.