新疆汉族乙醇依赖患者家庭暴力行为与谷氨酸受体6基因多态性关联分析

Association between polymorphism of GluR6 gene and domestic violence in patients with alcohol dependence of Han people in Xinjiang

目的探讨谷氨酸受体-6(GluR6)基因rs6922753、rs2227283位点多态性与新疆汉族乙醇依赖患者家庭暴力行为之间的关系。方法 184例乙醇依赖患者按照有无家庭施暴分为施暴组104例和无施暴组80例,采用聚合酶链反应产物直接测序法检测2组患者GluR6基因rs6922753、rs2227283位点的多态性分布。应用SPSS 17.0软件分析基因多态性与暴力行为的相关性。结果在施暴组与无施暴组之间,rs6922753位点基因型频率分布差异有统计学意义(P=0.018),等位基因频率分布差异有统计学意义(P=0.007)。在施暴组与无施暴组之间,rs2227283位点基因型频率分布差异有统计学意义(P=0.023),等位基因频率分布差异有统计学意义(P=0.019)。与rs6922753 CC比较,rs6922753 TT使家庭暴力的发生风险升高了2.859倍。与rs6922753 CC+CT相比较,rs6922753 TT使家庭暴力的发生风险升高了2.116倍。与rs2227283 GG比较,rs2227283 AG使家庭暴力的发生风险升高了1.194倍。结论新疆汉族乙醇依赖患者家庭暴力行为可能与GluR6基因多态性具有关联性。

Objective To investigate the association between glutamate receptor-6（GluR6）gene polymorphism and domestic violence in patients with alcohol dependence of Han people in Xinjiang. Methods The methods of polymerase cain reaction and DNA sequencing technique were conducted to detect rs6922753 and rs2227283 single nucleotide polymorphism of GluR6 gene in a 104 domestic violence perpetrators on patients with alcohol dependence and 80 no domestic violence perpetrators on patients with alcohol dependence. The association between the polymorphisms and violent behavior was analyzed by SPSS 17. 0 software. Results The frequence of genotype（P = 0. 018） and allele（P = 0. 007） of rs6922753 polymorphisms in the domestic violence group were statistically different from those in the no domestic violence group;the frequence of genotype（P =0.023） and allele（P =0.019） of rs2227283 polymorphisms in the domestic violence group were statistically different from those in the no domestic violence group. Compared with rs6922753 CC,the occurrence risk of domestic violence increased2. 859 times made by rs6922753 TT. Compared with rs6922753 CC ＋ CT,the occurrence risk of domestic violence increased2. 116 times made by rs6922753 TT. Compared with rs2227283 GG,the occurrence risk of domestic violence increased 1. 194 times made by rs2227283 AG. Conclusion GluR6 gene polymorphism may be associated with domestic violence in patients with alcohol dependence of Han people in Xinjiang.