Ki-67、雌激素受体及孕激素受体在子宫肌瘤中的表达

Expressions of Ki-67,estrogen receptor and progesterone receptor in uterine leiomyoma

目的探讨Ki-67、雌激素受体(ER)及孕激素受体(PR)在子宫肌瘤中的表达及临床意义。方法采用免疫组织化学法检测52例子宫肌瘤标本和52例瘤旁正常子宫肌层标本中Ki-67、ER及PR的表达情况,分析Ki-67、ER及PR的表达与子宫肌瘤的相关性。结果正常子宫肌层与子宫肌瘤组织中ER、Ki-67的表达比较差异均无统计学意义(P>0.05),子宫肌瘤组织中PR的表达显著高于正常子宫肌层(P<0.05)。子宫肌瘤组织中PR、ER、Ki-67的表达与肿瘤数量及部位无显著相关性(P>0.05)。肿瘤直径>5 cm的子宫肌瘤与肿瘤直径<5 cm的子宫肌瘤组织中PR、Ki-67的表达比较差异均无统计学意义(P>0.05)。肿瘤直径>5 cm的子宫肌瘤组织中ER的表达显著高于肿瘤直径<5 cm的子宫肌瘤(P<0.01)。结论 PR可能参与了子宫肌瘤的发生和发展,ER与子宫肌瘤的大小有关。

Objective To investigate the clinical significance of the expressions of Ki-67,estrogen receptor（ER） and progesterone receptor（PR） in uterine leiomyoma. Methods The expressions of Ki-67,ER and PR in 52 uterine leiomyoma specimens and 52 peritumoral normal myometrium specimens were detected by immunohistochemical method. The relativity between the expressions of Ki-67,ER,PR and uterine leiomyoma was analyzed. Results There was no significant difference in the expressions of ER and Ki-67 in normal myometrium and uterine leiomyoma（ P〉0. 05）. The expression of PR in uterine leiomyoma was significantly higher than that in normal myometrium（P〈0. 05）. The expressions of Ki-67,ER and PR in uterine leiomyoma had no obviously relativity to the number and position of tumor（P〉0. 05）. There was no significant difference in the expressions of PR and Ki-67 in uterine leiomyoma of diameter above 5 cm and diameter less than 5 cm（P〉0. 05）. The expression of ER in uterine leiomyoma of diameter above 5 cm was significantly higher than that in uterine leiomyoma of diameter less than 5 cm（P〈0. 01）. Conclusion PR may participate in the occurrence and development of uterine leiomyoma. ER is related to the size of uterine leiomyoma.