基于DNA损伤修复的分子靶向治疗:肿瘤靶向治疗的新篇章

Targeting DNA repair pathways: a new episode in targeted cancer therapeutics

2009年美国临床肿瘤学会（American Society of Clinical Oncology,ASCO）报道一种全新的分子靶向药物可选择性抑制DNA修复相关的关键酶——聚腺苷二磷酸核糖聚合酶-1[poly（ADP-ribose）polymerase-1,PARP-1],对三阴乳腺癌患者有效。这一突破性成果强烈预示以DNA损伤修复通路为靶标的分子治疗可能成为肿瘤治疗的新策略。

DNA,as the fundamental material carrying genetics information,is consistently challenged by endogenous and exogenous stimuli,including oxidative stress,ionizing irradiation,and chemotherapeutic agents,just to name a few. DNA repair mechanisms are then essential for cell survival under stress. Altered DNA repair networks is one of the most important features of cancer cells,which makes targeting DNA repair pathways an emerging strategy in cancer therapeutics. We reviewed the evolving variety of strategies and current potent clinical drug candidates in DNA repair targeting therapeutics.