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基于中国文献的循证医学评价老年抑郁症患者P300变化

Study of P300 in senile patients with depression: a meta-analysis of domestic literatures
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摘要 目的 分析老年抑郁症患者P300潜伏期和波幅的变化. 方法 在中国生物医学文献数据库(CBM)以及中文科技期刊全文数据库(CNKI)进行检索,同时联合手工检索对国内发表的13项符合本研究标准的文献应用RenMan4.1进行Meta分析. 结果 老年抑郁症患者与老年健康对照组P300的潜伏期比较,抑郁症组患者N1、P2、N2和P3潜伏期比对照组显著延长[N1:加权均数差(WMD) =3.07,95%可信区间(CI):0.70~5.42,Z=2.55,P=0.010;P2:WMD=18.41,95%CI:15.11~21.71,Z=10.93,P<0.010;N2:WMD=25.41,95%CI:12.80~29.02,Z=13.80,P<0.010;P3:WMD=32.14,95%CI:24.14~34.88,Z=23.04,P<0.010];与健康对照组比较,老年抑郁症组患者的P2、N2和P3波幅显著降低(P2:WMD=-0.83,95%CI:-1.07~-0.59,Z=6.78,P<0.010;N2:WMD=-0.34,95%CI:-0.59~-0.08,Z=2.57,P=0.010;P3:WMD=-2.54,95%CI:-2.75~-2.33,Z=23.99,P<0.010). 结论 老年抑郁症P300的潜伏期明显延长,波幅明显降低. Objective To assess the latency and amplitude changes in P300 in senile patients with depression.Methods 13 domestic published study literatures meeting our criteria were searched from CBM,CNKI,and a meta-analysis on P300 latency and amplitude was performed with RenMan 4.1 soft ware.Results 1.The P300 latency in senile patients with depression was significant longer than that in senile normal controls in N1,P2,N2,P300 (N1:WMD=3.07,95 % CI:0.7~5.42,Z=2.55,P=0.010;P2:WMD=18.41,95%CI:15.11~21.71,Z=10.93,P< 0.01;N2:WMD=25.41,95%CI:12.80~29.02,Z=13.80,P<0.01;P3:WMD=32.14,95%CI:24.14~34.88,Z=23.04,P<0.01).2.The amplitude in senile patients with depression was significant lower than that in senile normal controls in N2,P2,P3 (P2:WMD=-0.83,95%CI:-1.07~-0.59,Z-6.78,P<0.01; N2:WMD=-0.34,95%CI:-0.59~-0.08,Z=2.57,P=0.01;P3:WMD=-2.54,95%CI:-2.75~-2.33,Z=23.99,P<0.010).Conclusions P300 longer latency and lower amplitude are the statistically characterized features for senile depressive patients.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2014年第11期1235-1237,共3页 Chinese Journal of Geriatrics
基金 国家中医药管理局中医心理学重点学科项目(国中医药人教发2012-32) 浙江省中西医结合中医临床心理学项目(2012-XK-A02) 浙江省立同德医院院级课题(2008024)
关键词 抑郁症 META分析 Depressive disorder Meta-analysis
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