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重视痴呆的鉴别诊断 被引量：4

The differentiation of dementia
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摘要 多种因素可以影响人的认知功能而导致痴呆,如梅毒感染、维生素缺乏、血氨增高、一氧化碳中毒、副肿瘤综合征等非特异性炎性疾病以及血管病和变性病.仅变性病引起的痴呆也不仅仅有阿尔茨海默病、额颞叶变性、路易体病、正常颅压脑积水、朊蛋白病等简单的分类,而是依据蛋白分类为tau蛋白病,包括阿尔茨海默病（Alzheimer＇s disease,AD）、额颞叶变性（frontal temple lobe degeneration,FTLD）、皮层基底节变性、进行性核上性麻痹、仅神经元纤维缠结的痴呆、银颗粒病、全脑胶质tau蛋白病、痴呆伴脊髓性肌萎缩.而根据tau蛋白的不同又可进一步分为3R优势的tau蛋白病如Pick＇s病、FTDP-17;4R优势的tau蛋白病如嗜银颗粒病、FTDP-17;另有3R和4R混合的tau蛋白病如AD额叶变异型、神经纤维缠结型痴呆、散发的多系统tau蛋白病以及FTDP-17.另外还有TDP43蛋白病、FUS蛋白病、α-synuclein突触核蛋白病、POLY-Q多谷氨酸病以及Prion病.然而,临床工作中人们往往过多地诊断阿尔茨海默痴呆和血管性痴呆,而忽视了一些可治性因素,耽误了治疗,甚至忽视易引起患病的混合因素而导致痴呆.
作者 高晶
机构地区 中国医学科学院北京协和医学院北京协和医院神经科
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2014年第11期1257-1259,共3页 Chinese Journal of Geriatrics
关键词 痴呆 诊断 鉴别 Dementia Diagnosis, differential
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献12

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二级参考文献6

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共引文献10

同被引文献38

  • 1中华医学会神经病学分会帕金森病及运动障碍学组 中华医学会神经病学分会神经心理学与行为神经病学组.帕金森病痴呆的诊断与治疗指南[J].中华神经科杂志,2011,.
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引证文献4

二级引证文献41

中华老年医学杂志
2014年 第11期

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