手术联合吲哚美辛口服治疗颅骨多发嗜酸细胞肉芽肿患儿一例

Surgical treatment combined with oral administration of indomethacin for eosinophilic granuloma of the skull:report of a pediatric case

一例13岁女孩因为头痛5d入院，CT检查提示其颅骨三处病变分别为大小约2．5cm×3．2cm，1．2cm×1．0cm，0．3cm×0．3cm。患者最大一处病变接受手术切除，术后病理证实为嗜酸细胞肉芽肿。而后给予其吲哚关辛片25mg每天两次口服，应用3个月，患者耐受良好。术后3个月及1年CT复查提示未手术处病变进行性缩小，术后1年时新生骨组织基本替代原病变缺损。

A 13-year-old girl presented headache for 5 d upon admission to hospital. An initial CT revealed 3 lesions located in her skull, the sizes of which were 2.5 cm ×3.2 cm,1.2 cm × 1.0 cm,0.3 cm ×0.3 cm, respectively. The largest lesion was resected by surgery and confirmed as eosinophilic granuloma by pathology. After surgery, she took oral indomethacin 25 mg b. i. d for 3 months and tolerated it well. CT scan was performed 3 months and 1 year later, and the results showed that the unresected lesions shrank progressively and the defected bones were regenerated and healed one year later after operation.