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瞬时受体电位通道蛋白6参与血管紧张素Ⅱ诱导足细胞损伤的信号传导机制 被引量：2

Signal transmission of TRPC6 and AⅡ-induced podocyte injury
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摘要 足细胞表达瞬时受体电位通道蛋白6(TRPC6),TRPC家族是一类能通透钙离子的非选择性阳离子通道,近年来,研究发现TRPC6参与了血管紧张素Ⅱ(AngⅡ)诱导足细胞损伤的病理生理过程。本文就TRPC6一般特性及参与AngⅡ诱导足细胞损伤的信号传导机制作一简述。 Podocytes express canonical transient receptor potential-6 （TRPC6）, which is a nonselective, Ca（2＋）-permeable, cationic channel. Increasing evidence indicates that TRPC6 is involved in AII-induced podocytc injury through pathological calcium signaling in glomerular pathophysiology. This study summarizes the properties of TRPC6 and the signal transmission mechanisms of TRPC6-mediated and AII -induced podocyte injury.
作者 蔡佳盈 沈世忠 万建新
机构地区 福建医科大学附属泉州市第一医院肾内科 福建医科大学附属第一医院肾内科
出处 《肾脏病与透析肾移植杂志》 CAS CSCD 北大核心 2014年第5期458-461,448,共5页 Chinese Journal of Nephrology,Dialysis & Transplantation
关键词 瞬时受体电位通道蛋白6 钙离子 血管紧张素Ⅱ 足细胞损伤 信号传导 TRPC6 Ca2＋ Angiotensin Ⅱ podocyte injury transmission mechanisms
分类号 R692 [医药卫生—泌尿科学]
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参考文献37

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肾脏病与透析肾移植杂志
2014年 第5期

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