补体相关性肾病

Complement-relative kidney diseases

补体级联反应是一种免疫防御机制,能够有效诱导细胞凋亡、增强细胞免疫。补体的过度活化或调节异常参与多种慢性肾脏病及移植排斥反应的发生发展。补体在肾组织内活化、沉积与肾脏病临床及病理特点密切相关,亦在移植肾缺血再灌注损伤、细胞介导的排斥反应和抗体介导的排斥反应中发挥重要作用。近年来,针对补体的靶向性治疗已成肾脏病领域内新的研究热点,与肾脏病相关的抗补体治疗聚焦于抗C5单克隆抗体、C5受体拮抗剂、C1抑制剂和补体受体1等针对补体不同环节的药物。本文对补体相关性肾病及靶向抗补体治疗肾脏病的最新研究进展加以综述。

Complement casecade is a kind of immunologic defensive mechanism which can effectively induce cellular apoptosis and enhance cellular immunology. Complement overactivation and dysregulation play an important role in the development of many chronic kidney diseases and rejection after transplantation. The location of complement activation within the kidney parenchyma is associated with the pathologic and clinical features of kidney diseases and ischemia- reperfusion injury, antibody-mediated rejection and cell-mediated rejection of transplanted kidneys. Recently, complement- targeting therapies have become a surge of interest in the region of nephrology, focusing on anti-C5 monoclonal antibody, C5 receptor antagonist, CI inhibitor and Complement receptor 1. This review focuses on anticomplement drugs in complement-relative kidney disease.