噻托溴铵联合沙美特罗/氟替卡松对老年支气管哮喘患者肺通气功能的改善

Effects of tiotropium bromide and salmeterol/fluticasone propionate on lung function in old patients with bronchial asthma

目的:探讨联合吸入噻托溴铵和沙美特罗/氟替卡松对老年支气管哮喘患者肺通气功能的影响。方法:将本院呼吸内科100例确诊为支气管哮喘的患者随机分为吸入噻托溴铵和沙美特罗/氟替卡松治疗组43例,沙美特罗/氟替卡松组29例,噻托溴铵组28例。治疗6个月后,观察治疗疗效、治疗前后肺功能变化及治疗后肺功能改善率。结果:联合吸入噻托溴铵和沙美特罗/氟替卡松组的总有效率为88.4%,明显高于噻托溴铵组的67.9%和沙美特罗/氟替卡松组的72.4%,差异具有统计学意义,P<0.05。同时联合吸入噻托溴铵和沙美特罗/氟替卡松组的肺功能改善率高于其他两组,改善更显著,差异具有统计学意义。结论:噻托溴铵联合沙美特罗/氟替卡松能明显改善支气管哮喘患者肺通气功能,疗效显著。

AIM：To explore the effects of tiotropium bromide combined with salmeterol/fluticasone propionate on lung function in old patients with bronchial asthma.METHODS：Totally 100 patients with bronchial asthma were randomly divided into three groups,the fisrt group（43）was given tiotropium bromide and salmeterol/fluticasone propionate,the second group（28）was given tiotropium bromide only,the last group（29）was given salmeterol /fluticasone propionate only.All patients underwent pulmonary function test before the treatment and 6months after the therapy. RESULTS：The total effective rate was 88.4%in the first groupthat was given tiotropium bromide and salmeterol/fluticasone propionate and 67.9% in the second group-that was given tiotropium bromide only,72.4% in the last group-that was given salmeterol/fluticasone propionate only with significant difference（P〈0.05）.The lung functions of the three groups were obviously improved after the treatment,and the improvement was more pronounced in the first group than in the another groups（P〈0.05）.CONCLUSION：The combination of tiotropium bromide and salmeterol/fluticasone propionate can improve lung function more significantly.