脓毒症的生物标记物

Biomarkers of sepsis

脓毒症是病原微生物入侵机体引起的全身性炎症反应综合征,进一步发展将演变为重症脓毒症或脓毒症休克。脓毒症已成为危重症病人的首要死因,如何早期识别预警、及时的诊断、有效地防治脓毒症的发生发展是改善患者预后的关键,生物标记物在其中具有重要的作用。然而,目前临床上尚无敏感性、特异性均高的生物标记物。基于促炎抗炎反应失衡和免疫功能抑制的生物标记物,以及PIRO分级系统中表观遗传标记、单核苷酸变异和基因拷贝等将为脓毒症的预警和诊治提供科学依据。

Sepsis,the leading cause of death in critically ill patients ,is a systemic inflammatory response syndrome caused by pathogens ,which could further develop into severe sepsis or septic shock .Early recognition , timely diagnosis ,effective prevention and treatment are critical to improve the outcome of sepsis .Biomarkers play a significant role in the prognosis and diagnosis of sepsis .While none of these biomarkers have sufficient specificity or sensitivity to be employed in clinical practice .Biomarkers based on the abnormal inflammatory response and immu-nosuppression ,combining with epigenetic markers , single nucleotide polymorphism and gene duplication of PIRO Stratification System will provide scientific basis for early alert ,diagnosis and treatment of sepsis .