期刊文献+

线粒体功能障碍在糖尿病及其心肌病中的作用 被引量:2

Roles of mitochondrial dysfunction in diabetes and diabetic cardiomyopathy
原文传递
导出
摘要 糖尿病是严重危害人类健康的常见病,然而其发病机制并不完全清楚.线粒体的主要功能是合成ATP为机体提供能量,此外还在活性氧产生、细胞钙稳态和细胞凋亡中起重要的调节作用.导致线粒体功能障碍的重要原因包括氧化应激、钙紊乱、线粒体生物合成减少、线粒体内膜通透性转变孔道开放以及线粒体DNA突变等.越来越多的研究表明,线粒体功能障碍不仅与1型糖尿病的β-细胞功能障碍有关,也与2型糖尿病的胰岛素抵抗密切相关,还在糖尿病心肌病的发生发展中起重要作用.笔者就线粒体功能障碍与糖尿病及其心肌病的研究现状作一综述,有助于认识并深入研究线粒体功能障碍在糖尿病中的重要作用,为阐明糖尿病的发病机制及其临床防治拓开新思路. Diabetes mellitus is a common disease of serious harmful to human health,but its pathogenesis is not entirely clear.Mitochondria are the important organelles to generate energy in eukaryocytes,and play a pivotal role in the regulation of reactive oxygen species generation,intracellular calcium homeostasis,and apoptosis signal transduction.The possible causes of mitochondrial dysfunction include oxidative stress,Ca^2+ disturbances,reduction of mitochondrial biosynthesis,opening of mitochondrial permeability transition pore,mitochondrial DNA mutations,and etc..Many studies demonstrate that mitochondrial dysfunction is associated with β-cell dysfunction of type 1 diabetes mellitus and insulin resistance of type 2 diabetes mellitus.Moreover,mitochondrial dysfunction plays important roles in the development of diabetic cardiomyopathy.This present article reviewed the current status of studies on the relationship of mitochondrial dysfunction and diabetes mellitus and diabetic cardiomyopathy.It is very important to understand and study mitochondrial dysfunction and its important roles in diabetes mellitus and diabetic cardiomyopathy in order to clarify the pathogenesis of diabetes mellitus and explore new approaches of prevention and treatment for diabetes mellitus.
作者 熊燕 方伟进
出处 《中国医师杂志》 CAS 2014年第10期1297-1302,共6页 Journal of Chinese Physician
基金 国家自然科学基金资助项目(81170778)、广东省科技计划资助项目(20138021800098)、广州市科技计划资助项目(2014J4100067)
关键词 线粒体/病理学 糖尿病 胰岛素抗药性 糖尿病并发症 Mitochondria/pathology Diabetes mellitus Insulin resistance Diabetes complications
  • 相关文献

参考文献35

  • 1Guaxiguata L,Whiting DR,Hambleton I,et al.Global estimates of diabetes prevalence for 2013 and projections for 2035[J].Diabetes Res Clin Pract,2014,103 (2):137-149.
  • 2Chen N,Leng YP,Xu WJ,et al.Contribution of endogenous inhibitor of nitric oxide synthase to hepatic mitochondrial dysfunction in streptozotocin-induced diabetic rats[J].Cell Physiol Biochem,2011,27(3-4):341-352.
  • 3Li N,Brun T,Cnop M,et al.Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction[J].J Biol Chem,2009,284(35):23602-23612.
  • 4Yarana C,Sripetchwandee J,Sanit J,et al.Calcium-induced cardiac mitochondrial dysfunction is predominantly mediated by cyclosporine A-dependent mitochondrial permeability transition pore but not mitochondrial calcium uniporter[J].Arch Med Res,2012,43(5):333-338.
  • 5Sheng B,Wang X,Su B,et al.Impaired mitochondrial biogenesis contributes to mitochondrialdysfunction in Alzheimer's disease[J].J Neurochem,2012,120(3):419-429.
  • 6Kleiner S,Mepani R J,Laznik D,et al.Development of insulin resistance in mice lacking PGC-1α in adipose tissues[J].Proc Nail Acad Sci USA,2012,109(24):9635-9640.
  • 7Taddeo EP,Laker RC,Breen DS,et al.Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle[J].Mol Metab,2013,3(2):124-134.
  • 8Montaigne D,Marechal X,Coisne A,et al.Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients[J].Circulation,2014,130(7):554-564.
  • 9Lu H,Koshkin V,Allister EM,et al.Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes[J].Diabetes,2010,59(2):448-459.
  • 10Rydén A,Faresj(o) M.Altered immune profile from pre-diabetes to manifestation of type 1 diabetes[J].Diabetes Res Clin Pract,2013,100(1):74-84.

同被引文献26

  • 1刘国辉,谢鼎华,朱纲华,伍伟景,葛圣雷.EGCG对H_2O_2诱导的螺旋神经节细胞MnSOD基因表达的影响[J].中南大学学报(医学版),2004,29(6):682-685. 被引量:3
  • 2LI W J, NIE S P, XIE M Y, et al. A major green tea component,(-)-epigallocatechin-3-gallate, ameliorates doxorubicin-mediatedcardiotoxicity in cardiomyocytes of neonatal rats[J]. Journal ofAgricultural and Food Chemistry, 2010, 58(16): 8977-8982.DOI:10.1021/jf101277t.
  • 3YANG C, LIU S Q, VENKATARAMAN S, et al. Structure-directingstar-shaped block copolymers: supramolecular vesicles for the deliveryof anticancer drugs[J]. Journal of Controlled Release, 2015, 208: 93-105.DOI:10.1016/j.jconrel.2015.03.027.
  • 4RHARASS T, VIGO J, SALMON J M, et al. New methodfor the detection of reactive oxygen species in anti-tumouralactivity of adriamycin: a comparison between hypoxic andnormoxic cells[J]. Free Radical Research, 2008, 42(2): 124-134.DOI:10.1080/10715760701834552.
  • 5KIM D S, WOO E R, CHAE S W, et al. Plantainoside D protectsadriamycin-induced apoptosis in H9c2 cardiac muscle cells via theinhibition of ROS generation and NF-κB activation[J]. Life Sciences,2007, 80(4): 314-323. DOI:10.1016/j.lfs.2006.09.019.
  • 6ZOROV D B, JUHASZOVA M, SOLLOTT S J. MitochondrialROS-induced ROS release: an update and review[J]. Biochimicaet Biophysica Acta (BBA)-Bioenergetics, 2006, 1757(5): 509-517.DOI:10.1016/j.bbabio.2006.04.029.
  • 7张润华, 王贤和, 陈萍, 等. 表没食子儿茶素没食子酸酯增强食管癌细胞对阿霉素化疗敏感性[J] . 中华临床医师杂志(电子版), 2013(22): 10144-10147.
  • 8CHEN L, YE H, ZHANG G, et al. Autophagy inhibition contributesto the synergistic interaction between EGCG and doxorubicin tokill the hepatoma Hep3B cells[J]. PLoS ONE, 2014, 9(1): e85771.DOI:10.1371/journal.pone.0085771.
  • 9SAEED N M, EL-NAGA R N, EL-BAKLY W M, et al.Epigallocatechin-3-gallate pretreatment attenuates doxorubicininducedcardiotoxicity in rats: a mechanistic study[J]. BiochemicalPharmacology, 2015, 95(3): 145-155. DOI:10.1016/j.bcp.2015.02.006.
  • 10GOORMAGHTIGH E, POLLAKIS G, PRAET M, e t a l .Free radicals formation and membrane damages induced byadriamycin in mitochondria: a study in vivo and in vitro[J].Archives of Physiology & Biochemistry, 2008, 92(2): BP12-BP13.DOI:10.3109/13813458409071088.

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部