期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

热休克蛋白70对脑缺血性损伤的神经保护研究进展 被引量：1

原文传递
导出
摘要 缺血性脑血管病是严重威胁人类健康的常见病和多发病，在成人中患病率、病死率和致残率都较高。虽然对其发病机制的了解越来越深入，但目前仍缺乏有效的治疗方法。近来研究发现，脑缺血性损伤发生后除了引起一系列细胞分子水平上的反应导致损伤外，机体还启动内源性保护机制，促进某些特殊蛋白质的合成。
作者 张平 雷旭辉 杜文众 蒋传路
机构地区 哈尔滨医科大学附属第二医院神经外科
出处 《卒中与神经疾病》 2014年第5期314-316,共3页 Stroke and Nervous Diseases
基金 黑龙江省科学基金资助项目(编号为ZJY0604-02) 哈尔滨市科技创新人才研究专项资金项目(编号为2010RFXXS021)
关键词 脑缺血性损伤 热休克蛋白70 神经保护 缺血性脑血管病 内源性保护机制 细胞分子水平 人类健康 发病机制
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献17

  • 1Kim N,Kim JY,Yenari MA.Anti-inflammatory properties and pharmacological induction of HSP70 after brain injury.Inflammopharmacology,2012,20(3):177-185.
  • 2Sharp FR,Zhan X,Liu DZ.Heat Shock Proteins in the Brain:Role of Hsp70,HSP27,and HO-1(Hsp32)and their therapeutic potential.Transl.Stroke Res,2013,4(6):685-692.
  • 3Bao XQ,Liu GT.Bicyclol a novel antihepatitis drug with hepatic heat shock protein27/70 inducing activity and Cytoprotective effects in mice.Cell Stress Chaperones,2008,13(3):348.
  • 4Ouyang YB,Xu LJ,Emery JF,et al.Overexpressing GRP78 influences Ca(2+)handling and function of mitochondria in astrocytes after ischemia-like stress.Mitochondrion,2011,11(2):279-86.
  • 5Liu N,Deguchi K,Shang J,et al.In Vivo Optical Imaging of EarlyStage Apoptosis in Mouse Brain After Transient Cerebral Ischemia.J Neurosci Res,2010,88(16):3488-3497.
  • 6de la Rosa X,Santaluca T,Fortin PY,et al.In vivo imaging of induction of heat-shock protein-70 gene expression with fluorescence reflectance imaging and intravital confocal microscopy following brain ischaemia in reporter mice.Eur J Nucl Med Mol Imaging,2013,40(3):426-438.
  • 7Zhang X,Dequchi K,Yamashita T,et al.Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats.Brain Res,2010,9(1343):143-152.
  • 8邢变枝,陈晖,张苏明.缺血后处理对大鼠局灶性脑缺血再灌注损伤热休克蛋白70影响[J].卒中与神经疾病,2010,17(2):97-100. 被引量：7
  • 9Ma Y,Lu C,Li C,et al.Overexpression of HSPA12B protects against cerebral ischemia/reperfusion injury via a PI3K/Akt-dependent mechanism.Biochim Biophys Acta,2013,1832(1):57-66.
  • 10Xu L,Xiong X,Ouyang Y,et al.Heat shock protein 72(Hsp72)Improves long term recovery after focal cerebral Ischemia in mice.Neurosci Lett,2011,488(3):279-282.

二级参考文献14

  • 1熊利泽,杨静,徐宁,朱萧玲,朱妙章.缺血后处理对大鼠局灶性脑缺血再灌注损伤的影响[J].中华麻醉学杂志,2005,25(7):508-510. 被引量：29
  • 2Pignataro G,Meller R,Inoue K,et al.In vivo and in vitro characterization of a novel neuroprotective strategy for stroke:ischemic postconditioning.J Cereb Blood Flow Metab,2008,28(2):232-241.
  • 3Soncin F,Zhang X,Chu B,et al.Transcriptional activity and DNA binding of heat shock factor-l involve phosphorylation on threonine 142 by CK2.Biochem Biophys Res Commun,2003,303(2):700-706.
  • 4Zhao ZQ,Corvera JS,Halkos ME,et al.Inhibition of myocardial injury by ischemic postconditioning during reperfusion:comparison with ischemic preconditioning.Am J Physiol Heart Circ Physiol,2003(3),285(3):579-588.
  • 5Zhao H,Sapolsky RM,Steinberg GK,et al.Interrupting reperfusion as a stroke therapy:ischemic postconditioning reduces infarct size after focal ischemia in rats.J Cereb Blood Flow Metab,2006,26(9):1114-1121.
  • 6Liu X,Chen H,Zhan B,et al.Attenuation of reperfusion injury by renal ischemic postconditioning:The role of NO.Biochemical and Biophysical Research Communications,2007,359(3):628-634.
  • 7Zheng Z,Kim JY,Ma H,et al.Anti-inflammatory effects of the 70kDa heat shock protein in experimental stroke.J Cereb Blood Flow Metab,2008,28(1):53-63.
  • 8Ouyang YB,Xu LJ,Sun YJ,et al.Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress.Cell Stress & Chaperones,2006,11(2):180-186.
  • 9Johannes G,Lassmann MH,Johansen FF.Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus.Neurobiology of Disease,2007,25(3):582-593.
  • 10Xing B,Chen H,Zhao D,et al.Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat.Stroke,2008,39(8):2362-2369.

共引文献6

同被引文献14

引证文献1

卒中与神经疾病
2014年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部