碳酸酐酶Ⅳ与人类疾病

Carbonic Anhydrase Ⅳ and Human Diseases

碳酸酐酶4(carbonic anhydrase 4,CAIV)是12种人类相关碳酸酐酶中的一员,主要通过糖基磷脂酰基醇锚定在细胞质膜上。哺乳动物的多个器官有CAIV的表达。CAIV高效催化CO2的水化和HCO3–的脱水反应,在尿液酸化、肺泡换气等生理反应中起重要作用。CAIV基因表达的变化、结构稳定性的破坏和活性的改变等均与人类多种疾病的发生发展密切相关。CAIV还可以作为药物治疗靶点应用于疾病治疗。为此,该文就CAIV与人类相关疾病发生的病理生理机制作一综述。

Carbonic anhydrase 4（CAIV） is one of the 12 kinds of human-related carbonic anhydrases.It anchored in the cytoplasmic membranein mainly by glycosylphosphatidylinositol.The expression of CAIV has been identified in multiple organs of mammals.CAIV efficiently catalyzes the reaction of CO2 hydration and HCO3– dehydration,and plays an important role in many physiological response,such as acidification of urine,alveolar ventilation,etc.CAIV gene expression changes,structural instability and activity loses are closely related to the development of many human diseases.CAIV can also be applied as a drug target for treatment of diseases.To this end,this paper draws a summary for the association between CAIV and the pathophysiology of human diseases.