摘要
自噬是细胞降解自身长寿命蛋白、受损细胞器或入侵病原体,以维持自身稳态的现象。最近,利用全基因组关联扫描技术发现,ATG16L1、IRGM等自噬相关基因的单核苷酸多态性与克罗恩病的发生有关。该文综述了这些自噬相关基因多态性以及细胞自噬缺陷与克罗恩病发生发展过程的关系。
Autophagy is the process that cells maintain normal cellular homeostasis by degrading longlived protein and damaged organelles.Recently,several Crohn's disease associated genes have been identified by genome-wide association scan,including autophagy related gene ATG16L1 and IRGM.In this review,we summarized the role of autophagy deficiency in the pathogenesis of Crohn's disease.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2014年第11期1592-1596,共5页
Chinese Journal of Cell Biology