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粪钙卫蛋白与儿童肠道发育及疾病相关性的研究进展 被引量：3

Research advances in the role of fecal calprotectin in intestinal development and diseases among children
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摘要 钙卫蛋白是S100蛋白家族中的一种钙、锌结合蛋白,由中性粒细胞表达具有重要的细胞外功能。该文综述了粪钙卫蛋白与儿童肠道发育的相关性及影响因素,以及粪钙卫蛋白在儿童肠道病理状态下如坏死性小肠结肠炎、炎症性肠病、肠道感染、乳糜泻、过敏等疾病的诊断、随访、复发的评估及治疗的反应程度上的应用进展。进一步的研究还需要深入了解粪钙卫蛋白在儿科生理及病理过程中的实际作用。 Calprotectin is a calcium-and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity. This paper reviews current findings concerning the relationship between faecal calprotectin and intestinal development among children, inlfuencing factors of fecal calprotectin and the implication of faecal calprotectin in the diagnosis, follow-up, assessment of relapses, and response to treatment in pediatric intestinal diseases, such as necrotizing enterocolitis, inlfammatory bowel disease, intestinal infection, celiac disease and allergy. Further studies are required to provide insights into the actual role of calprotectin in physiological and pathological processes in pediatrics.
作者 李锋 盛晓阳
机构地区 上海交通大学医学院附属新华医院儿童与青少年保健科/上海市儿科医学研究所/教育部环境与儿童健康重点实验室
出处 《中国当代儿科杂志》 CAS CSCD 北大核心 2014年第10期1064-1069,共6页 Chinese Journal of Contemporary Pediatrics
基金 上海市儿科学重点学科(T0204) 上海市医学重点学科(05Ⅲ002)资助项目 上海市科学技术委员会浦江人才计划(08PJ14082) 国家自然科学基金(81172686 81302446)
关键词 钙卫蛋白 肠道疾病 儿童 Calprotectin Intestinal disease Child
分类号 R725.7 [医药卫生—儿科]
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参考文献45

  • 1Vaos G, Kostakis ID, Zavras N,et al. The role of calprotectin inpediatric disease[J]. Biomed Res Int, 2013,2013: 542363.
  • 2Roseth AG, Schmidt PN, Fagerhol MK. Correlation betweenfaecal excretion of indium-111 -labelled granulocytes andcalprotectin, a granulocyte marker protein, in patients withinflammatory bowel disease[J]. Scand J Gastroenterol, 1999,34(1): 50-54.
  • 3Fagerberg UL, Loof L, Merzoug RD, et al. Fecal calprotectinlevels in healthy children studied with an improved assay[J]. JPediatr Gastroenterol Nutr, 2003, 37(4): 468-472.
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  • 6Gisbert JP, McNicholl AG. Questions and answers on the role offaecal calprotectin as a biological marker in inflammatory boweldisease[J]. Dig Liver Dis, 2009, 41(1): 56-66.
  • 7Fagerberg UL, Loof L, Myrdal U, et al. Colorectal inflammationis well predicted by fecal calprotectin in children withgastrointestinal symptoms[J]. J Pediatr Gastroenterol Nutr,2005,40(4): 450-455.
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二级参考文献26

  • 1Baldassarre ME,Altomare MA, Fanelli M, et al. Does calprotectin represent a regulatory factor in host defense or a drug target in in- fllammatory disease? Endocr Metab Immune Drug Targets,2007, 7(1) :1-5.
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  • 3Roseth AG, Schmidt PN, Fagerhol MK. Correlation between faecal excretion of indium-I 11 -labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease. Scand J Gastroenterol, 1999,34 ( 1 ) :50-54.
  • 4Bunn SK, Bisset WM, Main MJ, et al. Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel dis- ease. J Pediatr Gastroenterol Nutr,2001,32(2) :171-177.
  • 5Campbell DI, Lunn PG, Ella M. Age-related association of small intestinal mucosal enteropathy with nutritional status in rural Gambian children. Br J Nutr,2002,88 (5) :499-505.
  • 6Gisbert JP, McNicholl AG. Questions and answers on the role of faecal calprotectin as a biological marker in inflammatory bowel disease. Dig Liver Dis,2009,41 ( 1 ) :56-66.
  • 7Bremner A, Roked S, Robinson R, et al. Faecal calprotectin in children with chronic gastrointestinal symptoms. Acta Paediatr, 2005,94 ( 12 ) : 1855-1858.
  • 8Canani RB ,Terrin G, Rapacciuolo L, et al. Faecal calprotectin as reliable non-invasive marker to assess the severity of mucosal in- flammation in children with inflammatory bowel disease. Dig Liver Dis,2008,40 ( 7 ) :547-553.
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  • 10Fagerberg UL, Loof L, Myrdal U, et al. Coloreetal inflammation is well predicted by fecal calprotectin in children with gastrointesti- nal symptoms. J Pediatr Gastroenterol Nutr, 2005,40 ( 4 ) : 450- 455.

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中国当代儿科杂志
2014年 第10期

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