期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

甲巯咪唑致多关节炎综合征1例 被引量：8

Methimazole-induced Polyarthritis: A Case Report
原文传递
导出
摘要 1例23岁女性甲状腺功能亢进症患者接受甲巯咪唑(30mg?d-1)治疗6周后出现多发、游走性关节肿痛,查白细胞、C-反应蛋白水平升高,血沉增快,抗核抗体(ANA)1:320,抗中性粒细胞胞浆抗体(ANCA)、类风湿因子(RF)、抗链球菌溶血素O(ASO)阴性。停用甲巯咪唑1周后症状好转,1月后症状完全缓解,复查抗核抗体1:100。 A 23-year-old female with hyperthyroidism developed migratory polyarthritis 6 weeks after starting therapy with methimazole （30mg daily）. Her clinical laboratory tests showed increased total white blood cel count, elevated C-reactive protein level and erythrocyte sedimentation rate and the level of antinuclear antibody （ANA） was 1：320. Test results were negative for the presence of anti-neutrophil cytoplasmic antibodies （ANCAs）, rheumatoid factor （RF） and anti-streptolysin O （ASO）. Her symptoms were improved 1 week after methimazole was withdrawn, and completely disappeared 1 month later. The test result of ANA analysis was 1：100.
作者 安艳华 王旭东 曹秋梅
机构地区 首都医科大学附属北京同仁医院综合内科
出处 《临床药物治疗杂志》 2014年第6期60-62,共3页 Clinical Medication Journal
关键词 甲巯咪唑 药物不良反应 多关节炎综合征 methimazole adverse drug reaction polyarthritis
分类号 R977.14 [医药卫生—药品]
  • 相关文献

参考文献15

  • 1Cooper DS. Antithyroid drugs[J]. N Engl J Med, 2005, 352(9):905-917.
  • 2Rafter GW. Methimazole and arthritis[J]. Scand J Rheumatol, 1990, 19(5):385.
  • 3Wing S, Fantus IG. Adverse immtmologic effects of antithyroid drugs[J]. CMAJ, 1987, 136(2):121-127.
  • 4Cooper DS. The side effects of antithyroid drugs[J]. Endocrinologist, 1999, 9 (6):457476.
  • 5Nob JY, Yasuda S, Sato S, et al. Clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody- associated vasculitis caused by antithyroid drugs[J]. J Clin Endocrinol Metab, 2009, 94(8): 2806-2811.
  • 6Morita S, Ueda Y, Eguchi K. Anti-thyroid drug induced ANCA-associated vaseulitis: a case report and review of the literature[J]: Endocr J, 2000, 47(4): 467-470.
  • 7Sera N, Ashizawa K, Ando T, et al. Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves' disease[J]. Thyroid, 2000, 10(7): 595-599.
  • 8Gunton JE, Stiel J, Clifton-Bligh P, et al. Prevalence of positive anti-neutrophil cytoplasmic antibody (ANCA) in patients receiving anti-thyroid medication[J]. Eur J Endocrinol, 2000, 142(6):587-590.
  • 9Jiang X, Khursigara G, Rubin RL. Transformation of lupus inducing drugs to cytotoxic products by activated neutrophils[J]. Science, 1994, 266(5186):810-813.
  • 10Hess E. Drug-related lupus[J]. N Engl J Med, 1988, 318(22): 1460-1462.

同被引文献50

  • 1吴凤岐.儿童关节炎的诊断思考[J].中国医刊,2005,40(6):20-21. 被引量：4
  • 2张涛,华川,陈如泉.复方甲亢片治疗甲亢114例临床分析[J].浙江中西医结合杂志,2007,17(2):91-92. 被引量：4
  • 3Cooper DS. Antithyroid Drugs[J]. N Engl J Med, 2005,352(9):905 -917.
  • 4Gum6 M, Salinas I, Reverter JL, et al, Frequency of anti neutrophil cytoplasmic antibody in Graves, disease pa- tients treated with methimazole [J ]. J Clin Endocrinol Metab,2003,88(5) :2141-2146.
  • 5Wada N, Mukai M,Kohno M, et al. Prevalence of serum anti-myeloperoxidase antineutrophil cytoplasmic antibod- ies (MPO-ANCA) in patients with Graves, disease trea- ted with propylthiouracil and thiamazole [J]. Endocr J, 2002,49(3) :329-334.
  • 6Noh JY, Yasuda S,Sato S, et al. Clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody-as- sociated vasculitis caused by antithyroid drugs[J]. J Clin Endocrinol Metab, 2009,94(8) : 2806- 2811.
  • 7Gao Y, Zhao MH, Guo XH, et al. The prevalence and tar- get antigens of antithyroid drugs induced antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with hyperthyroidism[J]. Endocr Res, 2004,30 (2) : 205-213.
  • 8Shikha D, Harris J, Resta C, et al. Antineutrophilic cyto- plasmic antibody positive vasculitis associated with me- thimazole use [J]. Case Rep Endocrinol, 2015, 2015:530319.
  • 9Yasude T, Kishida D,Tazawa K, et al. ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole[J]. Intern Med,2012, 51(22) :3177-3180.
  • 10Ploegstra WM,Boontje RP, Kamps AW. Arthritis associ- ated with antithyroid therapy in a 15-year-old girl[J]. J Pediatr Pharmacol Ther,2011,16(2):98-101.

引证文献8

二级引证文献24

临床药物治疗杂志
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部