浙新霉素对皮肤癣菌的体外抗真菌活性研究

Study on Antifungal Activities of Zhexinmycin against Dermatophytes in vitro

目的：评价浙新霉素体外抗真菌活性。方法：采用CLSI推荐的M-38A方案测定浙新霉素对7种皮肤癣菌最小抑菌浓度（MIC）及最小杀菌浓度（MFC）。结果：浙新霉素对7种皮肤癣菌的MIC范围为0.125-2.000μg·ml^-1,MFC范围为0.250-4.000μg·ml^-1。结论：浙新霉素具有较强的抗真菌活性,能抑制和杀灭絮状表皮癣菌、红色毛癣菌、紫色毛癣菌、犬小孢子菌、须癣毛癣菌、断发毛癣菌、石膏样小孢子菌等多种皮肤癣菌。

Objective： To evaluate in vitro antifungal activities of zhexinmycin against dermatophytes. Methods： The minimum inhibitory concentration（ MIC） and the minimum fungicidal concentration（ MFC） of zhexinmycin against 7 strains of dermatophytes were determined by using broth microdilution method according to CLSI M-38 A. Results： The MIC of zhexinmycin against dermatophytes was within the range of 0. 125-2. 000 μg·ml^-1. The MFC was within the range of 0. 250-4. 000 μg·ml^-1. Conclusion： Zhexinmycin shows strong in vitro antifungal effect on multiple fungi such as Epidermophyton floccosum,Trichophyton rubrum,Trichophyton violaceum,Microsporum canis,Trichophyton mentagrophytes,Trichophyton tonsurans and Microsporum gypseum.