摘要
目的:探讨邻苯二甲酸二丁酯(DBP)对大鼠精子的生成和质量影响。方法:150只雄性大鼠,随机分为DBP低剂量组(50 mg·kg-1)、DBP中剂量组(200 mg·kg-1)、DBP高剂量组(1 000 mg·kg-1)、空白对照组(蒸馏水)和溶剂对照组(花生油),每组30只,每天灌胃给药,每30d每组取10只大鼠解剖取样,称量睾丸、附睾质量,取一侧附睾进行精子计数、精子存活率和精子形态分析。结果:灌胃90 d,DBP中、高剂量组精子数、精子存活率、睾丸、附质重量及其脏器系数均明显降低(P<0.05或0.01)。结论:长期大剂量使用DBP对大鼠生殖功能有毒性作用。
Objective： To evaluate the effects of dibutyl phthalate on rat sperm production and quality. Methods： Totally 150 male rats were randomly divided into the low dose group（ 50 mg·kg^-1）,the middle dose group（ 200 mg·kg^-1）,the high dose group（ 1000 mg·kg^-1）,the blank control group and the solvent control group（ peanut oil as the control） with 30 ones in each. After continuous administration for every 30 days,10 rats from each group were anatomized,the weight of testes and epididymides were determined,and one side of epididymis was used to carry out the sperm analysis including counting,survival rate and morphology. Results： After intragastric administration for 90 days,the sperm count and survival rate,the weight of testis and epididymis and organ coefficient in the middle dose group and high dose group were decreased significantly（ P 0. 05 or 0. 01）. Conclusion： The long-term administration of dibutyl phthalate at high dose exhibits notable toxicity on rat reproductive function.
出处
《中国药师》
CAS
2014年第12期2019-2021,共3页
China Pharmacist
基金
青岛市公共领域科技支撑计划(编号:12-1-3-57-nsh)
